PMID: 9662001Jul 14, 1998Paper

Age-related changes in [3H]MK-801 binding in the Fischer 344 rat brain

Neurobiology of Aging
J J Mitchell, K J Anderson

Abstract

In this study we tested the hypothesis that the efficacy of L-glutamate to stimulate [3H]MK-801 binding to the NMDA receptor/channel complex is altered as a function of aging. L-Glutamate, or related excitatory amino acid (EAA), is the endogenous neurotransmitter of the NMDA receptor/channel complex. These studies examined the efficacy and potency with which L-glutamate produces receptor activation, channel opening and subsequent MK-801 binding as a function of increasing age by comparing dose-response curves (EC50 and Emax) from 6-, 12-, and 24-month-old F-344 rats. The number of NMDA receptors, as determined by [3H]MK-801 binding in the presence of a saturating concentration of L-glutamate, was reduced in the inner frontal cortex, entorhinal cortex and the lateral striatum in aged rats when compared with young adults. When a range of L-glutamate concentrations were used, differences in Emax were noted in the same brain regions in addition to several others in aged and middle-aged animals when compared with young-adult animals. No changes in EC50 values were noted in any of the brain regions at either age when compared with young-adults.

References

Mar 1, 1991·Neurobiology of Aging·G L WenkL C Cork
May 1, 1991·Neurobiology of Aging·R A GonzalesS W Leslie
Dec 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S KitoT Nomoto
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E Huettner, B P Bean
Mar 1, 1987·Neurobiology of Aging·G B Freeman, G E Gibson
Dec 8, 1987·The Journal of Comparative Neurology·P D ColemanM J West
Oct 1, 1984·Behavioral Neuroscience·L de Toledo-MorrellS Fleming
Apr 1, 1994·Neurochemical Research·M SerraG Biggio
Nov 26, 1993·Neuroscience Letters·Y Oster, M Schramm

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Citations

Feb 13, 2001·Mechanisms of Ageing and Development·G SegoviaF Mora
Mar 26, 2003·Brain Research. Molecular Brain Research·Mitsuko OkadaMichihiro Fujiwara
Nov 15, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A M Palmer
Nov 17, 2009·European Journal of Pharmacology·Alex V IarkovJeffrey N Joyce
May 16, 2008·Neuroscience·M C McCordP E Schauwecker
May 8, 2000·Journal of the American Geriatrics Society·B B Sherwin
Nov 3, 2012·Neurobiology of Aging·Natalie M ZahrAdolf Pfefferbaum
Apr 1, 2000·Addiction Biology·J MilosevićS Ruzdijić
Apr 16, 2018·Brain Imaging and Behavior·Raeesa GupteJanna L Harris
Jun 28, 2007·Metabolic Brain Disease·Thabelo Khoboko, Vivienne A Russell
Aug 5, 2000·Neurobiology of Aging·P MiganiL Piantanelli
Jul 31, 2021·Frontiers in Aging Neuroscience·Anna GasiorowskaGrazyna Niewiadomska

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