PMID: 11911505Mar 26, 2002Paper

Age-related changes in adrenergic neuroeffector transmission

Autonomic Neuroscience : Basic & Clinical
James R Docherty

Abstract

In this study we have looked at the effects of ageing on prejunctional control of noradrenergic neurotransmission in the cardiovascular system, in terms of alpha2-adrenoceptors, beta2-adrenoceptors and the noradrenaline re-uptake process. These studies show diminished prejunctional alpha2- and prejunctional beta-adrenoceptor-mediated responsiveness together with diminished noradrenaline re-uptake in rat tissues. The reduced prejunctional alpha2-inhibitory control and reduced re-uptake found in tissues from aged rats is more than likely to outweigh the effects of reduced beta-adrenoceptor facilitation, at least in normal conditions. Hence, assuming that such changes also occur in man, we might expect to find evidence of increased release of noradrenaline from noradrenergic nerves, and this could be reflected in plasma levels of noradrenaline.

References

May 27, 1976·Nature·M G ZieglerI J Kopin
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M C de Avellar, R P Markus
Aug 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·M Borton, J R Docherty
Apr 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·M C de AvellarR P Markus
Jan 1, 1988·Journal of Cardiovascular Pharmacology·T Bennett, S M Gardiner
Aug 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·M Borton, J R Docherty
May 1, 1987·Neurobiology of Aging·H H McIntosh, T C Westfall
Oct 1, 1971·Cardiovascular Research·J ConwayR Sannerstedt
Apr 1, 1997·British Journal of Clinical Pharmacology·M White, F H Leenen
Dec 30, 1998·Journal of Cardiovascular Pharmacology·D L SnyderJ Roberts

❮ Previous
Next ❯

Citations

Mar 17, 2012·Cellular and Molecular Neurobiology·Hamzeh ElayanMichael G Ziegler
Nov 30, 2011·Current Hypertension Reports·Michael G ZieglerMunir Gharaibeh
Nov 26, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Vladimir ZivkovićMiljana Pavlović
Feb 4, 2014·Seminars in Immunology·Caroline J Padro, Virginia M Sanders
Jan 22, 2008·Pediatric Neurology·Frans J M FeronJohan S H Vles
Oct 4, 2007·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Gineta LiutkieneAnita Dabuzinskiene
Mar 17, 2016·Journal of Physiology and Biochemistry·Eduardo Ortega
Apr 29, 2008·Neuroscience·M Di MauroF Santangelo
May 2, 2012·Journal of Neuroimmunology·Sam D PerezDenise L Bellinger
Aug 10, 2010·Neurobiology of Aging·Eduardo MouraMaria Augusta Vieira-Coelho
Nov 5, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Giuseppe RengoNicola Ferrara
Oct 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thad E WilsonChester A Ray
Aug 31, 2013·Circulation Research·Anastasios LymperopoulosWalter J Koch
May 22, 2007·Stress : the International Journal on the Biology of Stress·O KrizanovaL Kubovcakova
Jan 21, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zhong-Min WangOsvaldo Delbono
May 26, 2018·Cardiovascular Research·Tobias Bruegmann, Godfrey L Smith
Feb 22, 2021·Ageing Research Reviews·Osvaldo DelbonoMaria Laura Messi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.