PMID: 15374338May 1, 1993Paper

Age-related changes in blood and liver lipids of male Wistar rats

Archives of Gerontology and Geriatrics
A CantaforaR Verna

Abstract

The results of this study indicate that the age-dependent plasma cholesterol increase observed in male Wistar rats is correlated with changes in both the distribution of high-density lipoprotein fractions and the storage of hepatic cholesterol. Specifically, the lipoprotein distribution showed a significant increase in the proportion of HDL(1) and a symmetrical decrease in both the HDL(2) and HDL(3) fractions during the 3 month to 18 month age period. There were no significant changes in the very-low density and low-density lipoprotein fractions. The chemical composition of lipoproteins showed many age-related variations, especially in the proportion of cholesteryl ester and in the distribution of HDL subfractions. A study of fatty acyl composition of the major lipid classes showed that, within cholesteryl ester found in liver, there was an increase in the proportion of saturated fatty acids. Polyunsaturated fatty acids increased in the cholesteryl esters found in high-density lipoproteins of older rats. These observations suggest that the age-dependent accumulation of body cholesterol occurs by a reduced catabolism of HDL(1) fraction, and modifications in plasma and liver lipids.

References

Sep 1, 1977·CRC Critical Reviews in Toxicology·J E Gray
Jan 1, 1979·Experimental Gerontology·D Hollander, D Morgan
Dec 1, 1978·Mechanisms of Ageing and Development·S Malhotra, D Kritchevsky
Oct 1, 1992·Bioscience Reports·R RivabeneE Bravo
Oct 1, 1991·Biochimica Et Biophysica Acta·W J JohnsonM C Phillips
Oct 1, 1990·Lipids·R R Brenner
Feb 1, 1991·The Journal of Clinical Investigation·S EricssonB Angelin
Jan 1, 1986·Methods in Enzymology·T M Forte, R W Nordhausen
Apr 1, 1988·Atherosclerosis·N E MillerJ J Albers
Jan 1, 1987·Experimental Gerontology·Y S ChoiM Sugano
Nov 1, 1987·Mechanisms of Ageing and Development·Y S ChoiT Ide
Jan 1, 1986·Methods in Enzymology·M J Chapman
Mar 15, 1974·Experientia·J A Story, D Kritchevsky
May 1, 1971·Atherosclerosis·M Yamamoto, Y Yamamura
Dec 1, 1969·Experimental Gerontology·Z Hrůza, M Wachtlová
Jul 6, 1984·Biochimica Et Biophysica Acta·D E Newton, J M Shaw
Jan 1, 1981·Annals of Nutrition & Metabolism·D R IllingworthP Alaupovic
Jan 1, 1992·Archives of Gerontology and Geriatrics·A CantáforaR Verna

❮ Previous
Next ❯

Citations

Jun 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·R MasellaA Cantafora
Jul 26, 2008·Archives of Gerontology and Geriatrics·G MehmetçikM Uysal

❮ Previous
Next ❯

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.