PMID: 8983032Jan 1, 1997Paper

Age-related changes in c-fos mRNA induction after open-field exposure in the rat brain

Neurobiology of Aging
A H Nagahara, R J Handa

Abstract

In the present study, functional activation of brain regions was measured by the induction of c-fos and c-jun mRNA following exposure to a novel open field. Fischer 344 rats at 5 months, 14 months, and 21 months were exposed to a square open field for 20 min. Rats were then immediately sacrificed and their brains were examined for c-fos and c-jun mRNA using in situ hybridization. Control rats were sacrificed directly from their home cage. Results showed no significant age-related changes in locomotor activity. Autoradiogram analyses showed that open-field exposure induced c-fos mRNA throughout the brain, while c-jun mRNA was induced in a few brain regions. Aged rats showed a lower elevation of c-fos mRNA in the prelimbic cortex compared to 5-month rats. In addition, grain analyses revealed age-related decreases in c-fos mRNA induction in the medial prefrontal cortex, caudate, and ventral lateral septum. These findings indicate age-related changes in the induction of c-fos mRNA in certain brain regions following exploration of a novel environment.

References

Apr 1, 1976·Experimental Neurology·J O'Keefe
Jan 1, 1992·Brain Research. Molecular Brain Research·K J Mack, P A Mack
Apr 1, 1992·Journal of Neurochemistry·A J ColeJ M Baraban
Sep 1, 1992·Brain Research Bulletin·P Rogue, G Vincendon
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K M RosenG D Mower
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L L Brown
Mar 30, 1992·Neuroscience Letters·N Onoda
Sep 1, 1991·Brain Research. Molecular Brain Research·M SimonatoJ O McNamara
Dec 17, 1991·Brain Research. Developmental Brain Research·O Carmi, M Leon
Jan 1, 1991·Annual Review of Biochemistry·H R Herschman
Mar 1, 1991·Journal of Neurochemistry·J Venugopal, K S Rao
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K A Sherman, E Friedman
Jul 13, 1990·Science·A Gibbons
Sep 1, 1988·Neurobiology of Aging·C A Barnes
Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
Jul 1, 1981·Journal of Neurochemistry·E D LondonS I Rapoport
Jun 1, 1980·Brain : a Journal of Neurology·C B SmithL Sokoloff
Jun 1, 1994·Trends in Neurosciences·J Sergent
Feb 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E KitrakiF Stylianopoulou
May 31, 1994·Annals of the New York Academy of Sciences·G S Roth, J A Joseph
Mar 1, 1994·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M LiottiP T Fox
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·S KapurG M Brown
Jan 1, 1993·Mechanisms of Ageing and Development·M K ThakurY Natori
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·R J HandaS A Lorens

❮ Previous
Next ❯

Citations

Apr 28, 2005·Experimental Brain Research·Meritxell Torras-GarciaIsabel Portell-Cortés
Apr 16, 2004·Behavioural Brain Research·Peter SalchnerNicolas Singewald
Apr 20, 2001·Brain Research. Molecular Brain Research·R Basheer, P J Shiromani
May 16, 2002·Neurobiology of Aging·Julie A Markham, Janice M Juraska
Jul 14, 1998·Neurobiology of Aging·D J BucciM Gallagher
Jun 6, 2003·Brain Research Bulletin·Terence V Sewards, Mark A Sewards
Aug 4, 2005·Learning & Memory·Karin RichterMario Engelmann
Dec 3, 1998·Alcoholism, Clinical and Experimental Research·Q ShiM A Emanuele
May 14, 2010·PloS One·Makoto WadaShigeru Kitazawa
Jul 26, 2011·Behavioural Brain Research·Ksenia Z MeyzaJolanta Zagrodzka
Feb 13, 2003·The European Journal of Neuroscience·Khalid TouzaniRobert Jaffard
Dec 23, 2014·Acta Neuropsychiatrica·Daniele C AguiarFrancisco S Guimarães
May 28, 2011·Journal of Psychopharmacology·F A MoreiraF S Guimarães
Nov 23, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michelle RocheJohn P Kelly
Dec 25, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janitza L Montalvo-OrtizHongxin Dong
Jul 18, 2000·Acta Oto-laryngologica. Supplementum·T KuboY Nakai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.