PMID: 3755361Jul 16, 1986Paper

Age-related changes in calcium and phosphorus uptake by rat small intestine

Biochimica Et Biophysica Acta
H J Armbrecht

Abstract

The purpose of these experiments was to determine whether there are changes in intestinal Ca and P uptake with age and whether the regulation of Ca and P uptake changes with age. Experiments were performed in male Fischer 344 rats aged 2-3 months (young), 12-14 months (adult) and 22-24 months (old). Ca and P uptake were measured simultaneously by incubating everted intestinal sacs in a buffered salt solution containing radiolabeled 0.25 mM Ca and 1.0 mM P for 15 min. Ca uptake declined by over 50% with age in the duodenum, and P uptake showed a similar decline in both the duodenum and jejunum. The biggest decrease was seen between the young and adult age groups. These decreases in uptake were paralleled by decreases in serum 1,25-dihydroxyvitamin D with age. Administration of 1,25-dihydroxyvitamin D-3 increased Ca uptake by 50-65% in the duodenum and increased P uptake by 85-120% in the duodenum and jejunum of both young and adult rats. Although 1,25-dihydroxyvitamin D-3 increased uptake by about the same percentage in each age group, the maximal uptake was much greater in the young than in the adult. Feeding a low-Ca diet increased duodenal Ca uptake by 68% and increased serum 1,25-dihydroxyvitamin D over 2-fold in young rats....Continue Reading

References

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Citations

Nov 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Boass, S U Toverud
Jul 19, 2005·Journal of Mammary Gland Biology and Neoplasia·Ronald L HorstTimothy A Reinhardt
Sep 30, 1987·Mechanisms of Ageing and Development·M ShirakiG S Roth
Jun 1, 1987·Mechanisms of Ageing and Development·W G Doubek, H J Armbrecht
Mar 15, 1990·Mechanisms of Ageing and Development·C TrevesM T Vincenzini
Jul 1, 1987·Neurobiology of Aging·G E Gibson, C Peterson
Jan 1, 1993·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R SchleifferF Raul
Nov 19, 2003·Archives of Biochemistry and Biophysics·H J ArmbrechtM E H Bruns
May 16, 1997·Molecular and Cellular Endocrinology·G BaloghR Boland
Oct 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S J Marx, J Barsony
May 20, 1998·Archives of Biochemistry and Biophysics·H J ArmbrechtM E Bruns
Apr 12, 2005·Archives of Biochemistry and Biophysics·Alex J BrownH James Armbrecht
Dec 26, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·H J ArmbrechtT L Hodam
Dec 15, 1994·Annals of the New York Academy of Sciences·M L Michaelis
Jul 17, 1999·The American Journal of Physiology·H J ArmbrechtV B Kumar
Apr 23, 1990·Biochimica Et Biophysica Acta·S TakamotoC T Liang
Oct 20, 1988·Biochimica Et Biophysica Acta·H J ArmbrechtS B Porter

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