PMID: 8583832Sep 15, 1995Paper

Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron

Mechanisms of Ageing and Development
T AmanoK Yamamoto

Abstract

Altered localization and cellular level of three distinct lysosomal proteinases, cathepsins B (CB), L (CL), and D (CD), with aging were investigated in the rat trigeminal ganglion (TG) by immunohistochemical and quantitative analyses. At the light microscopic level, the intracytoplasmic distribution of these three enzymes was found to change with aging: These lysosomal proteinases in the TG of young rats (2-3 months of age) were widely and evenly distributed throughout the cytoplasm as coarse intracytoplasmic granules, whereas they were localized at focal cytoplasmic sites of the TG neurons of aged rats (28-31 months of age) as coarse aggregates. A similar distribution was observed with a major lysosomal membrane sialoglycoprotein having an apparent molecular mass of 107 kDa (LGP107). The cellular distribution of the three cathepsins as well as LGP107 in the TG neurons of aged rats corresponded well with that of autofluorescent lipofuscin. At the electron microscopic level, the age-related redistribution of these cathepsins in the TG neurons was found to be due to their great accumulation in autolysosomes localized at the focal perinuclear sites. The cellular levels of CB and CL determined by activity measurement in the TG of t...Continue Reading

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Citations

Sep 5, 2002·Free Radical Biology & Medicine·Ulf T Brunk, Alexei Terman
Oct 3, 2003·Ageing Research Reviews·Hiroshi Nakanishi
Jan 2, 2001·Neuropathology : Official Journal of the Japanese Society of Neuropathology·C TamagakiT Kinoshita
Sep 4, 2008·Antioxidants & Redox Signaling·Violetta N PivtoraikoJohn J Shacka
Apr 9, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Terman, U T Brunk
Mar 5, 2011·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·N L RendakovN N Nemova
May 13, 2008·Investigative Ophthalmology & Visual Science·Paloma B LitonDavid L Epstein
Nov 16, 2013·Molecular Neurobiology·Anja Pišlar, Janko Kos
Mar 28, 2009·Regulatory Peptides·Hans ImbodenJuan M Saavedra
Feb 20, 2007·Experimental Neurology·Wiebke WendtChristine C Stichel
Jul 21, 2005·The British Journal of Dermatology·C-L YangK Langlands
Dec 14, 2002·Annals of the New York Academy of Sciences·Atsushi NagaiSeung U Kim
Feb 4, 2006·Neurobiology of Aging·Sabrina S Seehafer, David A Pearce

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