Age-related changes in choroid plexus and blood-cerebrospinal fluid barrier function in the sheep

Experimental Gerontology
R L ChenJane E Preston

Abstract

Dysfunction of the choroid plexuses (CPs) and the blood-cerebrospinal fluid barrier (BCSFB) might contribute to age-related cognitive decline and neurodegenerative disease. We used the CPs from young (1-2 years), middle-aged (3-6 years) and old (7-10 years) sheep to explore effects of aging on various aspects of CP and BCSFB functions. Total protein in the cerebrospinal fluid (CSF) was significantly higher in old compared to young sheep and CSF secretion by the CP perfused in situ was significantly lower in both old and middle-aged when compared to young sheep, which correlated with reduced (22)Na(+) uptake and efflux by the CP. Steady-state extractions of a low and medium size molecular weight extracellular space marker, (14)C-mannitol and (3)H-polyethylene glycol, respectively, were significantly higher in CPs from old compared to young animals; however, there was no significant difference in steady-state extraction of a high molecular weight marker, (125)I-bovine serum albumin. This indicates increased passive BCSFB permeability for small and medium sized molecules in old sheep. CP redox activity was significantly lower in the old animals as assessed by the MTT assay, however, there was no significant difference in ATP conte...Continue Reading

Citations

Aug 6, 2009·Cerebrospinal Fluid Research·Jean-Claude ThiéryBenoit Malpaux
Sep 26, 2013·Fluids and Barriers of the CNS·Reynold Spector, Conrad E Johanson
Apr 13, 2012·Fluids and Barriers of the CNS·Mohammad NabiuniJaleel A Miyan
Nov 4, 2011·Nature Reviews. Neuroscience·Berislav V Zlokovic
May 8, 2015·Neurochemical Research·Nadia Aalling JessenMaiken Nedergaard
Mar 20, 2010·Journal of Neurochemistry·Ruo-Li ChenJane Elizabeth Preston
Jan 3, 2015·Journal of Neuroscience Methods·Jason K KarimyJ Marc Simard
May 3, 2011·Brain Research·Christine LagaraineJean-Claude Thiery
Feb 24, 2015·Frontiers in Cellular Neuroscience·Ibrahim González-MarreroRafael Castro-Fuentes
May 5, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Nina GorléRoosmarijn E Vandenbroucke
Dec 23, 2016·Annals of the American Thoracic Society·Roosmarijn E. Vandenbroucke
Jun 24, 2017·The Neuroradiology Journal·Banu AliciogluNail Bulakbasi
Jan 10, 2018·Stroke; a Journal of Cerebral Circulation·Marie-Gabrielle DuperronStéphanie Debette
May 31, 2020·Diagnostics·Jasleen KaurQuan Jiang
Apr 17, 2019·International Journal of Molecular Sciences·Michelle A Erickson, William A Banks
Jul 30, 2020·Molecular Neurobiology·Ajmal AhmadMohammad Moshahid Khan
May 1, 2020·Nature Communications·P G EvansJ A Wells
Mar 7, 2020·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Mar 7, 2020·Advanced Drug Delivery Reviews·M J FowlerR W Sirianni
Feb 3, 2021·International Journal of Molecular Sciences·Justine ParisGuilhem Bousquet
May 1, 2021·Neuroscience and Biobehavioral Reviews·Inge C M VerheggenWalter H Backes
Jul 27, 2021·Frontiers in Neuroanatomy·Jasleen KaurQuan Jiang
Sep 21, 2021·Tissue Barriers·Valerie C AndersonWilliam D Rooney
Aug 5, 2020·Biochimica Et Biophysica Acta. Biomembranes·Ingrid KratzerHelen Stolp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Blood-Brain Barrier Transport in Neurodegeneration

The blood brain barrier is important for regulating the movement of biomolecules in and out of the brain. For example, membrane transporters in the blood brain barrier can be essential for regulating drug movement and dysregulation of these processes may play a role in neurodegeneration. This feed follows the latest research on this topic.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.