PMID: 15235233Jul 6, 2004Paper

Age-related changes in conventional and magnetization transfer MR imaging in elderly people: comparison with neurocognitive performance

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Ki Yeol LeeIk-Hwan Cho

Abstract

This study was designed to compare three different measures of the elderly human brain; the magnetization transfer ratio (MTR) histogram, the percentage of brain parenchymal volume, and the volume of T2 hyperintense areas in terms of correlations with the study subjects neurocognitive performance. Thirty-five healthy community-dwelling elderly volunteers aged 60-82 years underwent dual fast spin-echo (FSE) imaging and magnetization transfer imaging. A semi-automated technique was used to generate the MTR histogram, the brain parenchymal volume, and the T2 lesion volume. The subjects' neurocognitive performance was assessed by using the Korean-Mini Mental State Examination (K-MMSE) and additional tests. The peak height of the MTR (PHMTR), the percentage of brain parenchymal volume (PBV), and the normalized T2 lesion volume (T2LV) were compared between the normal group (Z score on the K-MMSE>/=-2, n=23) and the mild cognitive impairment group (Z score on the K-MMSE < -2, n=12), and these parameters were correlated with age and various neurocognitive performance scores. The PHMTR was significantly lower in the cognitively impaired subjects than the PHMTR in the normal subjects (p = 0.005). The PBV scores were lower in the cognitiv...Continue Reading

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Citations

Jul 26, 2005·Topics in Magnetic Resonance Imaging : TMRI·Matilde Inglese, Yulin Ge
Mar 19, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jay N Giedd
Apr 22, 2015·Journal of the Neurological Sciences·Nicola TambascoPaolo Calabresi
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mark A Horsfield
May 27, 2016·Current Opinion in Neurology·Marco BozzaliMara Cercignani
Jun 8, 2021·NMR in Biomedicine·M Ethan MacDonald, G Bruce Pike

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