Age-related changes in diagnoses, histological features, and survival in children with brain tumors: 1930-1979. The Childhood Brain Tumor Consortium

Neurosurgery
F H GillesE T Hedley-Whyte

Abstract

In the Childhood Brain Tumor Consortium database, the proportions of older children (> or = 11 yr) with pilocytic astrocytomas, fibrillary astrocytomas, and ependymomas significantly increased (P < 0.05) over the 50 years (1930-1979) of the study. The increased proportions of pilocytic astrocytomas occurred whether the tumors were located in the supratentorial or infratentorial compartments. The increases in fibrillary astrocytomas and ependymomas were found only within the supratentorial tumor location. Some histological features found in pilocytic astrocytomas (e.g., Rosenthal fibers, granular bodies, and very low cell density) were more likely to be found in older children. Other histological features were also more likely to be found in older children (e.g., parenchymal calcification, intertwined fascicles, intermediate and large-size nuclei, pleomorphic, elongated, or irregular nuclei, prominent nucleoli, multinucleated cells, thick hyaline blood vessels, hemosiderin, and parenchymal and perivascular lymphocytes). The probability of 5-year survival for young children with supratentorial ependymomas remained at approximately 0.4 in contrast to that for young children with infratentorial ependymomas, for whom it improved, bu...Continue Reading

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Citations

Feb 15, 1997·Cancer·L B Rorke
Sep 26, 2006·Pathology Oncology Research : POR·Ajay MalikChitra Sarkar
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Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Uri TaboriCynthia Hawkins
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Sep 10, 2014·Molecular Medicine Reports·Yoshinobu TakahashiJun-Ichi Kuratsu
Apr 19, 2000·Arquivos de neuro-psiquiatria·J S Reis FilhoL F Torres

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