Aug 22, 1983

Age-related changes in different steps of protein synthesis of liver and kidney of rats

FEBS Letters
H J GabiusF Cramer

Abstract

Protein synthesis in cell-free systems of rat liver and kidney decreases markedly with age. Examination of activity changes of the different steps revealed for both types of organs that reduced binding of aminoacyl-tRNA to ribosomes and reduced peptidyl transfer might be of major importance for the decrease in overall protein synthesis whereas ageing has only little effect on translocation as well as on initiation and termination.

  • References7
  • Citations25

Citations

Mentioned in this Paper

MT-TA gene
August Rats
Tissue Specificity
Triplet Codon-amino Acid Adaptor Activity
Transcription Initiation
Puromycin Dihydrochloride
Senility
Transfer RNA
Kidney
Protein Biosynthesis

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