Age-related changes in diffusion tensor imaging metrics of fornix subregions in healthy humans

Stereotactic and Functional Neurosurgery
David Qixiang ChenMojgan Hodaie

Abstract

White matter diffusivity measures of the fornix change with aging, which likely relates to changes in memory and cognition in older adults. Subregional variations in forniceal diffusivity may exist, given its heterogeneous anatomy and connectivity; however, these have not been closely examined in vivo. We examined diffusivity parameters (fractional anisotropy, FA; radial diffusivity, RD; axial diffusivity, AD) in forniceal subregions of healthy subjects and correlated them with age and hippocampal volume. Diffusion-weighted imaging and streamline tractography of the fornix were performed on 20 healthy, right-handed females (23-66 years). Six anatomical subregions were defined: midline (body, column, precommissural fornix) or lateral (fimbria, crura, postcommissural fornix). Regression analysis was performed comparing diffusivities against age. Hippocampal and ventricular volumes were also compared. Diffusivity values revealed statistical changes with age in both midline and lateralized subregions. The fornix body and left crus showed age-related alterations in all metrics (FA, RD, AD), whereas only right crus FA was altered. There was no significant change in hippocampal volumes, suggesting that forniceal changes may precede hi...Continue Reading

Citations

Jun 2, 2015·Frontiers in Systems Neuroscience·Dave J Hayes
Oct 30, 2016·Frontiers in Neuroanatomy·David Q ChenMojgan Hodaie
Sep 27, 2019·PloS One·Matthew R WalkerMojgan Hodaie
Sep 21, 2017·Frontiers in Neuroanatomy·Dave J HayesMojgan Hodaie
Mar 29, 2020·Brain and Neuroscience Advances·Bethany M CoadClaudia Metzler-Baddeley
Jul 7, 2021·Magnetic Resonance Imaging·Maria Fatima FalangolaJens H Jensen

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