Age-related changes in excitability and recurrent inhibition in the rat CA1 hippocampal region

The European Journal of Neuroscience
C Papatheodoropoulos, G Kostopoulos

Abstract

In hippocampal slices from male Wistar rats aged 1-34 months, we recorded the synaptic field potential responses of the CA1 neurons to stimulation of Schaffer collaterals. Eight electrophysiological indexes were extracted from input/output curves and compared in 11 age groups from 1 to 30 months. Neuronal excitability presented a U-shaped curve of development with a minimum at approximately 7-8 months of age. There was a significant continuous increase in neuronal excitability, i.e. a decrease in excitatory postsynaptic potential (EPSP) producing both the threshold and half-maximal population spike from middle age (8-10 months) to senescence (30 months). Synaptic efficiency also increased in old rats to reach a maximum during senescence, i.e. both the current for threshold EPSP and that for half-maximal EPSP reached a minimum in senescence, although the earlier developmental patterns of these two indexes were non-linear. The duration of the field EPSP elicited with maximal stimulation presented an abrupt decay after the first month. Aged animals presented a relatively small maximal population spike. Recurrent inhibition was most prominent on neuronal excitability rather than synaptic strength. Measured as the percentage change ...Continue Reading

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Citations

Mar 17, 2004·Journal of Neuroscience Methods·Armen SargsyanGeorge Kostopoulos
Aug 7, 1998·Brain Research. Developmental Brain Research·C Papatheodoropoulos, G Kostopoulos
Jan 24, 2002·Neurobiology of Aging·William AlmaguerJorge A Bergado
May 16, 2002·Neurobiology of Aging·M H Bassant, F Poindessous-Jazat
Dec 13, 2000·Experimental Gerontology·B PotierJ M Billard
Aug 1, 2012·Oxidative Medicine and Cellular Longevity·Carlos Clayton Torres AguiarSilvania Maria Mendes Vasconcelos
Sep 24, 2002·Neuropharmacology·D Steven KerrNicola Crawford
Jun 21, 2005·Ageing Research Reviews·D B Miller, J P O'Callaghan
Feb 1, 2011·Neurobiology of Aging·Emily M StanleyDavid D Mott
May 15, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Koki HirotaMitsuaki Yamazaki
Nov 8, 2005·Journal of Neuroscience Research·Evangelos SotiriouFevronia Angelatou

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