Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Annals of Nuclear Medicine
Axel Van Der GuchtPierre-Yves Marie

Abstract

The impact of age is crucial and must be taken into account when applying a voxel-based quantitative analysis on brain images from [¹⁸F]-fluorodeoxyglucose Positron Emission Tomography (FDG-PET). This study aimed to determine whether age-related changes in brain FDG-PET images are more accurately assessed when the conventional statistical parametric mapping (SPM) normalization method is used with an adaptive template, obtained from analysed PET images using a Block-Matching (BM) algorithm to fit with the characteristics of these images. Age-related changes in FDG-PET images were computed with linear models in 84 neurologically healthy subjects (35 women, 19 to 82-year-old), and compared between results provided by the SPM normalization algorithm applied on its dedicated conventional template or on the adaptive BM template. A threshold P value of 0.05 was used together with a family-wise error correction. The age-related changes in FDG-PET images were much more apparent when computed with the adaptive template than with the conventional template as evidenced by: (1) stronger correlation coefficients with age for the overall frontal and temporal uptake values (respective R² values of 0.20 and 0.07) and (2) larger extents of invol...Continue Reading

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Citations

Feb 16, 2016·Ageing Research Reviews·Takashi KatoKengo Ito
Jan 22, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sylvain PoussierPierre-Yves Marie
Aug 4, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sinn-Rithy TochAntoine Verger
Mar 19, 2019·Nuclear Medicine Communications·Clément DrouetPierre-Yves Marie
Mar 7, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Kai ZhangYasuyoshi Watanabe

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