Age-related changes in gastric mucosal repair and proliferative activities in rats exposed acutely to aspirin

Gerontology
M LeeI Cameron

Abstract

The present study was designed to determine whether there are any age-related changes in the repair of acute gastric mucosal injury induced by aspirin in Fischer 344 rats. We have also examined the influence of aging on gastric mucosal proliferative activities, a major component of gastric mucosal defense and repair mechanisms. Our data demonstrated that aging was associated with significant delays in both resolution of gross mucosal injury and regeneration of the injured gastric mucosa. However, there were no correlations between the regeneration of the injured gastric mucosa and gastric mucosal expression of proliferating cell nuclear antigen and transforming growth factor-alpha immunoreactivities.

Citations

Dec 1, 2007·Clinical Interventions in Aging·Julia L Newton
May 2, 2014·World Journal of Gastroenterology : WJG·Andrzej S TarnawskiMichael K Jones
Mar 25, 2008·Toxicology Letters·G Coelho-Palermo CunhaW Kaufmann
Oct 10, 2007·Clinics in Geriatric Medicine·Paul KuoMichael Horowitz
Dec 23, 2003·Alimentary Pharmacology & Therapeutics·J L NewtonF E B May
Nov 27, 2004·Mechanisms of Ageing and Development·J L Newton
Dec 21, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Amrita AhluwaliaAndrzej S Tarnawski
Jun 22, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Amrita AhluwaliaAndrzej S Tarnawski

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