PMID: 8469018Jan 1, 1993Paper

Age-related changes in homeostasis of inorganic sulfate in male F-344 rats

Mechanisms of Ageing and Development
S BakhtianR E Galinsky

Abstract

Advanced age is associated with a decline in renal function including decreased glomerular filtration rate, renal blood flow and renal tubular secretion. Endogenous inorganic sulfate homeostasis is maintained by concentration-dependent active renal reabsorption in the proximal tubule. The purpose of this study was to determine the effects of advanced age on: (1) the renal mechanisms for conserving endogenous inorganic sulfate and (2) the turnover of inorganic sulfate. Awake, male Fischer 344 rats age 4-5 months and 22-23 months received i.v. acetaminophen, 300 mg/kg, followed 2 h later by i.v. sodium sulfate, 2 mmol/kg, to lower and raise, respectively, plasma inorganic sulfate in order to measure the renal clearance of this anion from plasma at sub- and supraphysiologic concentration ranges. Another group of old and young male F-344 rats received a tracer injection of [35S]sodium sulfate to determine the effect of aging on the turnover of the endogenous inorganic sulfate pool. There was no statistically significant effect of advanced age on baseline plasma sulfate concentration or on the renal clearance of inorganic sulfate from plasma. The baseline excretion rate of inorganic sulfate in the senescent animals (0.38 +/- 0.25 mu...Continue Reading

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Citations

Dec 31, 1997·The Journal of Clinical Investigation·I FernandesC Silve
Sep 13, 2000·Critical Reviews in Clinical Laboratory Sciences·M E Morris, K Sagawa
Jun 11, 1999·The American Journal of Physiology·K PuttaparthiM Levi

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