PMID: 8602331Aug 1, 1995Paper

Age-related changes in immunoglobulin isotypes in whole and parotid saliva and serum in healthy individuals

Oral Microbiology and Immunology
S J ChallacombeP D Marsh

Abstract

Mucosal infections account for the majority of infections seen in elderly people, but little is known of whether mucosal immunity decreases with age. The objective of this study was to investigate the effect of age on the levels of salivary and serum immunoglobulins and the salivary immunoglobulin secretion rates in a healthy adult population. Healthy subjects (116 total) were divided into the following age groups: 20-39; 40-59; 60-79 and >80 years. Unstimulated (resting) whole and stimulated parotid saliva and serum were collected from all participants. Salivary and serum immunoglobulins were quantified by enzyme-linked immunosorbent capture assays. The levels of serum immunoglobulin G (IgG) and IgM were significantly reduced in the oldest age group, whereas no significant reduction in the level of IgA with age was observed. The IgG and IgA levels in whole saliva increased significantly in the oldest age group D, but no changes were detected in IgM levels. No significant changes in any immunoglobulin levels with age were found in parotid saliva. However, significant reductions in the secretion rates of IgA and IgM, but not IgG, in whole saliva were detected in the oldest age group. No significant changes in the secretion rates...Continue Reading

References

Jan 1, 1979·Journal of Gerontology·A Członkowska, J Korlak
Dec 1, 1992·Journal of Dental Research·D J SmithM A Taubman
Jul 1, 1992·Journal of Dental Research·P D MarshS J Challacombe
Jun 1, 1991·Oral Microbiology and Immunology·E CamlingB Krasse
Mar 1, 1991·Journal of Dental Research·D J SmithP Ali-Salaam
Jul 1, 1991·Journal of Medical Microbiology·R S PercivalP D Marsh
Feb 1, 1987·Journal of Dental Research·D J SmithJ L Ebersole
Jan 1, 1988·Archives of Oral Biology·F J Grundbacher
Nov 1, 1987·Journal of Clinical Immunology·D J SmithW F King
Jan 1, 1986·The Journal of Infectious Diseases·R GangulyL Vargas
May 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·M W Kalff
Aug 1, 1974·Archives of Oral Biology·D C ChandlerW T McFall
Apr 1, 1967·Acta Medica Scandinavica·R Norberg
Mar 1, 1984·Journal of Clinical Immunology·M S FinkelsteinM L Freedman
Jan 1, 1981·Annual Review of Microbiology·P C McNabb, T B Tomasi
Jan 1, 1981·Annual Review of Microbiology·J R McGhee, S M Michalek
Aug 1, 1994·Journal of Dental Research·R S PercivalP D Marsh
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·L T MackinnonG J Seymour

❮ Previous
Next ❯

Citations

Mar 6, 2010·Animal Health Research Reviews·John R Prickett, Jeffrey J Zimmerman
Sep 22, 2009·Journal of Proteome Research·Kiran S AmbatipudiJohn R Yates
Apr 12, 2002·Journal of the American Geriatrics Society·Jonathan A ShipBruce J Baum
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Adeline R WhitneyPatrick O Brown
Aug 25, 2000·Journal of Women's Health & Gender-based Medicine·B D ReedP Zazove
Apr 26, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A A BeharkaS Nibkin Meydani
Jan 5, 2002·Clinical and Diagnostic Laboratory Immunology·Timothy C GranadeBharat Parekh
Jun 30, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Agnieszka GornowiczKrzysztof Bielawski
Mar 14, 2014·Bioanalysis·Michael MacdonaldChamindie Punyadeera
Jan 1, 2013·Bioscience of Microbiota, Food and Health·Koji HamuroNoriyuki Kohda
Aug 1, 1996·European Journal of Oral Sciences·W A van der ReijdenA V Nieuw Amerongen
Dec 15, 2015·Journal of Biophotonics·Eva MelnikMichael Lämmerhofer
Jul 31, 2007·Archives of Oral Biology·S ChaushuG Bachrach
Feb 4, 2006·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Herenia P LawrenceDavid Locker
May 7, 2009·Oral Microbiology and Immunology·C K ChangD R Bienek
Sep 16, 2006·International Dental Journal·P D Marsh, R S Percival
Oct 6, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H PajukoskiR Sulkava
Dec 20, 2000·The Journal of Infection·R J DobbsC Weller
Aug 1, 1996·FEMS Immunology and Medical Microbiology·R S PercivalS J Challacombe
Feb 5, 2008·The Journal of the American Dental Association·Michael TurnerJonathan A Ship
Mar 17, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·E PaszynskaA Slopien
Jan 23, 2016·The British Journal of Dermatology·S AliJ F Setterfield
Mar 27, 2010·Brazilian Oral Research·Abdollah JafarzadehReza Vazirinejad
Aug 11, 2005·Brazilian Oral Research·Cristiane Yumi Koga-ItoAntonio Olavo Cardoso Jorge
Mar 18, 2004·European Journal of Clinical Investigation·D Weber-MzellJ Deutsch
Sep 22, 1998·Scandinavian Journal of Immunology·P StohlawetzP Pietschmann
Jul 10, 2002·Periodontology 2000·Per GjermoRui Oppermann
Oct 5, 2013·Clinical Microbiology Reviews·Janice M YoshizawaDavid T W Wong
Aug 23, 2006·Oral Microbiology and Immunology·N K ChildersS M Michalek
Feb 1, 1997·Oral Microbiology and Immunology·R S PercivalS J Challacombe
Mar 19, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elzbieta PaszynskaMonika Dmitrzak-Weglarz
May 25, 1999·Periodontology 2000·W P McArthur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.