PMID: 6104755Apr 1, 1980Paper

Age-related changes in inducible mouse liver enzymes: ornithine decarboxylase and tyrosine aminotransferase

Mechanisms of Ageing and Development
S Jacobus, D Gershon

Abstract

The time required to induce two inducible hepatic enzymes, ornithine decarboxylase (ODC) and tyrosine aminotransferase (TAT), by growth hormone and dexamethasone, respectively, increases with age. Specific activity at the peak of induction is the same for all ages. On the other hand, for basal TAT the specific activity per unit of TAT antigen was found to decrease considerably with age. The half-life of ODC was determined after cycloheximide administration. The apparent half-life at the peak of ODC induction increases from 15 minutes in 3-4-month-old mice to 30 minutes in 24-month-old animals. Loss of efficiency in the protein degradation system is implicated in this phenomenon as no apparent differences could be observed in the susceptibility of ODC and TAT from young or old mice to chymotrypsin. ODC and TAT are activated by temperatures of up to 37 degrees C and 50 degrees C, respectively. ODC is inactivated at 50 degrees C while TAT is inactivated at 76 degrees C. "Young" ODC and TAT are more readily activated or inactivated by heating than the "old" enzymes.

References

Apr 1, 1976·European Journal of Biochemistry·U Reiss, D Gershon
Apr 15, 1979·Archives of Biochemistry and Biophysics·H K SharmaM Rothstein
Feb 1, 1979·Mechanisms of Ageing and Development·D Gershon
Jan 1, 1979·The Biochemical Journal·A KallioJ Jänne
Feb 14, 1979·Biochemical and Biophysical Research Communications·H R Prasanna, R S Lane
Dec 1, 1979·Mechanisms of Ageing and Development·A Z Reznick, D Gershon
May 1, 1976·Archives of Biochemistry and Biophysics·H K SharmaM Rothstein
Nov 22, 1976·Biochemical and Biophysical Research Communications·U Reiss, D Gershon
Sep 1, 1977·Mechanisms of Ageing and Development·A Z Reznick, D Gershon
Aug 22, 1977·Biochemical and Biophysical Research Communications·T L Klug, R C Adelman
Sep 1, 1976·Journal of Cellular Physiology·W F Prouty
Jul 12, 1976·Biochemical and Biophysical Research Communications·O HebyC B Wilson
Jan 1, 1972·Advances in Enzyme Regulation·R C AdelmanB S Cohen
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H Gershon, D Gershon
Dec 1, 1969·The Journal of General Physiology·C E FinchA E Mirsky
Apr 16, 1971·Biochemical and Biophysical Research Communications·J S Bond
Dec 11, 1974·Biochemical and Biophysical Research Communications·U Reiss, M Rothstein
Apr 28, 1973·Biochimica Et Biophysica Acta·M OnoY Takeda
Sep 19, 1970·Nature·H Gershon, D Gershon
Jun 1, 1970·Endocrinology·D H RussellV J Medina
Sep 25, 1962·Biochemical and Biophysical Research Communications·O BARNABEI, F SERENI

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Citations

Feb 1, 1979·Mechanisms of Ageing and Development·D Gershon
Aug 1, 1984·Mechanisms of Ageing and Development·G Scalabrino, M E Ferioli
Aug 1, 1984·Mechanisms of Ageing and Development·A A Okada, J F Dice
Nov 1, 1985·Mechanisms of Ageing and Development·M VelezJ Satrústegui
Nov 30, 1988·Mechanisms of Ageing and Development·G J SarkisL A Jacobson
Dec 1, 1988·Archives of Gerontology and Geriatrics·M Prabhakaram, S N Singh
Jan 1, 1990·Experimental Gerontology·M Dellwo, R E Beauchene
Aug 1, 1983·Biological Reviews of the Cambridge Philosophical Society·S C Makrides
Nov 1, 1986·Biological Reviews of the Cambridge Philosophical Society·A M Holehan, B J Merry
Nov 1, 1984·Experimental Eye Research·K R Fleshman, B J Wagner
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ward, A Richardson
May 1, 1991·Molecular and Cellular Endocrinology·G ScalabrinoM E Ferioli

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