PMID: 9434002Jan 20, 1998Paper

Age-related changes in innervation in hypertrophic pyloric stenosis

Journal of Pediatric Surgery
H KobayashiP Puri

Abstract

Recent reports have identified abnormal innervation of the circular muscle layer involving the fine intramuscular nerve fibers in hypertrophic pyloric stenous (HPS). HPS presenting after 3 months of age is rare. The aim of this study was to determine the distribution pattern of nerve fibers in the smooth muscle layers in HPS and correlate this with age at presentation. Full-thickness pyloric muscle biopsy specimens were obtained from eight patients with HPS (five age 3 to 5 weeks, two age 3 months, and one age 7 months) and five controls with normal pylorus (age 5 days to 3 years). All specimens were stained with monoclonal antibody to the neural cell adhesion molecule (NCAM) using immunohistochemistry. There were many NCAM-positive nerve fibers in the circular and longitudinal muscle layers in the controls. No NCAM positive nerve fibers were seen in the circular or longitudinal muscle layers in the five cases of HPS in which the patients were less than 5 weeks old. In the two cases in which the patients were 3 months old, occasional NCAM-positive nerve fibers were seen in the circular layer, and moderate numbers of NCAM positive fibers were seen in the longitudinal muscle layers. Moderate numbers of NCAM-positive nerve fibers ...Continue Reading

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Citations

Sep 18, 2009·Pediatric Surgery International·Christina Panteli
Oct 22, 2008·Fertility and Sterility·Kohei OdagiriMitsuaki Suzuki
Oct 17, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Manfred Hauben, Guy W Amsden
Sep 15, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Sachie OnoElena Terui
Jan 5, 2002·Pediatric Annals·R W Letton

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