Age-related changes in intracellular cytokine profiles and Th2 dominance in allergic children

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Norio KawamotoNaomi Kondo

Abstract

The unbalanced T helper response has been pointed out in allergic diseases. Especially in childhood, it is important to consider the development of acquired immunity. We investigated the relationship between age and Th1, Th2, Tc1 or Tc2 cells. In addition, Th1, Th2, Tc1 or Tc2 cells in allergic diseases were compared with control subjects. Thirty-four healthy controls (0-40 years old), 200 samples of cord blood, nine patients with atopic dermatitis (AD) (1-3 years old) and five patients with bronchial asthma (BA) (2-6 years old) were studied. Surface staining with CD4, CD8 and intracellular staining with anti-interferon-gamma (IFN-gamma) and anti-interleukin (IL)-4 were carried out, and analyzed by using flow cytometry. In the healthy controls, the percentages of Th1, Tc1 or Th2 showed positive correlation with age. The absolute numbers of Th1 or Tc1 also correlated with age. Cord blood with a family history of allergic disease showed no significant difference compared to that without a family history. The percentage of Th2 in AD and BA patients was significantly higher than in the age-matched healthy controls. The increase in Th1, Th2 and Tc1 with age might reflect on the development of acquired immunity. Age matching is impor...Continue Reading

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Citations

Dec 15, 2011·Journal of Pediatric Gastroenterology and Nutrition·Seung PakMelvin B Heyman
Feb 21, 2008·American Journal of Clinical Dermatology·Gregoria I BetsiMatthew E Falagas
Jul 13, 2007·Toxicology Letters·Paurene DuramadNina T Holland
Dec 15, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Annika NelsonGiovanna Marchini
Mar 20, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Yujing FuLuo Zhang
May 7, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J O Warner
Feb 25, 2015·Journal of Clinical Pharmacology·Yi ZhangManish Gupta
Sep 8, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Masahiko KatoHiroyuki Mochizuki
Jan 21, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Masahiro MorimotoNaomi Kondo
Apr 3, 2014·European Journal of Nutrition·Beate WinklerVerena Wiegering
Sep 28, 2016·The Journal of Allergy and Clinical Immunology·Hitokazu EsakiEmma Guttman-Yassky
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Jun 6, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Takashi NomuraEmma Guttman-Yassky

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