Age-related changes in isolated mouse skeletal muscle function are dependent on sex, muscle, and contractility mode

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Cameron HillJason Tallis

Abstract

The present study aimed to simultaneously examine the age-related, muscle-specific, sex-specific, and contractile mode-specific changes in isolated mouse skeletal muscle function and morphology across multiple ages. Measurements of mammalian muscle morphology, isometric force and stress (force/cross-sectional area), absolute and normalized (power/muscle mass) work-loop power across a range of contractile velocities, fatigue resistance, and myosin heavy chain (MHC) isoform concentration were measured in 232 isolated mouse (CD-1) soleus, extensor digitorum longus (EDL), and diaphragm from male and female animals aged 3, 10, 30, 52, and 78 wk. Aging resulted in increased body mass and increased soleus and EDL muscle mass, with atrophy only present for female EDL by 78 wk despite no change in MHC isoform concentration. Absolute force and power output increased up to 52 wk and to a higher level for males. A 23-36% loss of isometric stress exceeded the 14-27% loss of power normalized to muscle mass between 10 wk and 52 wk, although the loss of normalized power between 52 and 78 wk continued without further changes in stress (P > 0.23). Males had lower power normalized to muscle mass than females by 78 wk, with the greatest decline ob...Continue Reading

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Citations

Jul 3, 2021·International Journal of Environmental Research and Public Health·Myong-Won SeoJong-Kook Song
Aug 4, 2021·Acta Biomaterialia·Kay LeichsenringMarkus Böl
Jul 2, 2021·Journal of Applied Physiology·Elizabeth A SchroderGerald S Supinski
Jun 26, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Trang TranSarah N Hilmer
Aug 28, 2021·International Journal of Molecular Sciences·Lucas C OlsonMichael J McClure
Oct 29, 2021·Journal of Cachexia, Sarcopenia and Muscle·Gretchen A Meyer, Karen C Shen

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Methods Mentioned

BETA
dissection
electrophoresis

Software Mentioned

GraphPad Prism
GraphPad
CEC Testpoint
SPSS
Testpoint

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