PMID: 8946255Dec 1, 1996Paper

Age-related changes in light-induced Jun-B and Jun-D expression: effects of transplantation of fetal tissue containing the suprachiasmatic nucleus

Journal of Biological Rhythms
A Cai, P M Wise

Abstract

Fos and Jun mRNA and peptide exhibit a daily light-induced rhythm in the suprachiasmatic nucleus (SCN). The authors previously have reported that Fos expression in the SCN is elevated prematurely during the dark, light-induced Fos expression is attenuated in middle-aged rats, and transplantation of fetal SCN tissue into the third ventricle of rats of this age restores the daily pattern of Fos expression to that of the young. Using immunocytochemistry, the authors performed the present study to determine whether Jun-B and Jun-D expression in the SCN is altered at the same stage during aging and, if so, whether transplantation of fetal tissue containing the SCN can restore the light-induced rhythms of these two immediate early genes. All groups of rats were transcardially perfused 90 min prior to and after light onset. In young rats, light induced a robust increase in the number of Jun-B positive cells in the SCN, whereas very few cells were labeled before light onset. In middle-aged rats, the light-induced increase in the number of Jun-B positive cells was significantly attenuated. Transplantation of fetal SCN tissue into the middle-aged rats successfully restored light-induced Jun-B expression to the levels of young rats. By co...Continue Reading

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Citations

Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Jun 18, 2002·Ageing Research Reviews·S R Pandi-PerumalD F Swaab
Jul 22, 2009·Ageing Research Reviews·Dietmar Weinert
Jun 27, 2008·Experimental Gerontology·Erin M GibsonLance J Kriegsfeld
Oct 23, 1998·Journal of Biological Rhythms·M W Hurd, M R Ralph
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·O Van ReethF W Turek
Jun 7, 2000·Chronobiology International·D Weinert
Dec 29, 2020·Journal of Neurochemistry·M Renate Buijink, Stephan Michel

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