Age-related changes in overcoming proactive interference in associative memory: The role of PFC-mediated executive control processes at retrieval

NeuroImage
Michael R Dulas, Audrey Duarte

Abstract

Behavioral evidence has shown age-related impairments in overcoming proactive interference in memory, but it is unclear what underlies this deficit. Imaging studies in the young suggest overcoming interference may require several executive control processes supported by the ventrolateral prefrontal cortex (VLPFC) and dorsolateral PFC (DLPFC). The present functional magnetic resonance imaging (fMRI) study investigated whether age-related changes in dissociable executive control processes underlie deficits in overcoming proactive interference in associative memory during retrieval. Participants were tasked with remembering which associate (face or scene) objects were paired with most recently during study, under conditions of high or low proactive interference. Behavioral results demonstrated that, as interference increased, memory performance decreased similarly across groups, with slight associative memory deficits in older adults. Imaging results demonstrated that, across groups, left mid-VLPFC showed increasing activity with increasing interference, though activity did not distinguish correct from incorrect associative memory responses, suggesting this region may not directly serve in successful resolution of proactive interf...Continue Reading

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Citations

Feb 23, 2019·Journal of Cognitive Neuroscience·Taylor JamesAudrey Duarte
Mar 29, 2019·Cerebral Cortex·Tarek AmerCheryl L Grady
Oct 9, 2018·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Emily C DugganMauricio A Garcia-Barrera
Aug 3, 2019·PsyCh Journal·Alexander VeraksaDaria Bukhalenkova
Jun 8, 2019·Journal of Cognitive Neuroscience·George SamraniJonas Persson
May 20, 2020·Journal of Cognitive Neuroscience·Brittany Corbett, Audrey Duarte
Mar 19, 2020·Medicina·Lindsay K CrawfordPaul D Loprinzi
Sep 16, 2020·Annual Review of Psychology·Michael C Anderson, Justin C Hulbert
Mar 8, 2021·Seminars in Cell & Developmental Biology·Myriam C SanderMarkus Werkle-Bergner

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