Age-related changes in parahippocampal white matter integrity: a diffusion tensor imaging study.

Neuropsychologia
E J RogalskiLeyla deToledo-Morrell

Abstract

The axons in the parahippocampal white matter (PWM) region that includes the perforant pathway relay multimodal sensory information, important for memory function, from the entorhinal cortex to the hippocampus. Previous work suggests that the integrity of the PWM shows changes in individuals with amnestic mild cognitive impairment and is further compromised as Alzheimer's disease progresses. The present study was undertaken to determine the effects of healthy aging on macro- and micro-structural alterations in the PWM. The study characterized in vivo white matter changes in the parahippocampal region that includes the perforant pathway in cognitively healthy young (YNG, n=21) compared to cognitively healthy older (OLD, n=21) individuals using volumetry, diffusion tensor imaging (DTI) and tractography. Results demonstrated a significant reduction in PWM volume in old participants, with further indications of reduced integrity of remaining white matter fibers. In logistic regressions, PWM volume, memory performance and DTI indices of PWM integrity were significant indicator variables for differentiating the young and old participants. Taken together, these findings suggest that age-related alterations do occur in the PWM region a...Continue Reading

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Oct 15, 1987·The Journal of Comparative Neurology·D G AmaralW M Cowan
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y GeinismanF Morrell
Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Jan 1, 1996·Neurobiology of Aging·T RasmussenM J West
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·T E ConturoM E Raichle
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A PfefferbaumM Moseley
Oct 12, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P J BasserA Aldroubi
Aug 20, 2002·American Journal of Alzheimer's Disease and Other Dementias·Barry ReisbergSunnie Kenowsky
Dec 19, 2002·NMR in Biomedicine·Michael Moseley
Jan 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G K RohdeC Pierpaoli
Aug 18, 2004·Neurobiology of Aging·Leyla deToledo-MorrellD A Turner
May 11, 2005·Neurology·T R StoubL deToledo-Morrell
Jul 12, 2005·Neurobiology of Aging·David MedinaGlenn T Stebbins
Jun 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Travis R StoubRaj C Shah
Aug 5, 2006·Neuroscience and Biobehavioral Reviews·Edith V Sullivan, Adolf Pfefferbaum
Oct 7, 2006·Neurobiology of Aging·Osamu AbeKuni Ohtomo
Apr 2, 2008·Neurobiology of Aging·Li-Hong ZhangZhan-You Wang
May 6, 2008·Neurobiology of Aging·D H SalatH D Rosas
Sep 24, 2008·Neurobiology of Aging·T R StoubL deToledo-Morrell
Nov 21, 2009·Neurobiology of Aging·Adam M BrickmanYaakov Stern
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A YassaCraig E L Stark
Oct 28, 2010·Brain Structure & Function·D BzdokSimon B Eickhoff
Aug 9, 2011·Neurobiology of Aging·Su Hee ChuRobert A Sweet

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Citations

Apr 9, 2013·Brain Imaging and Behavior·Jacob D BolzeniusRobert H Paul
Oct 8, 2013·Clinics in Geriatric Medicine·Caroline N HaradaKristen L Triebel
Jan 23, 2016·Aging Cell·Chand Parvez Danka MohammedKeetae Kim
Dec 25, 2015·Journal of Chemical Neuroanatomy·Federico W Grillo
Dec 18, 2013·CNS Neuroscience & Therapeutics·Bing ZhangKejal Kantarci
Mar 25, 2014·Neurobiology of Aging·Travis R StoubBradford C Dickerson
Aug 10, 2016·European Journal of Radiology·Ihsan YuceSuat Eren
May 18, 2017·Nutrition Research Reviews·Eva GatineauLaurent Mosoni
Dec 26, 2017·Frontiers in Aging Neuroscience·Lara IanovThomas C Foster
Sep 11, 2020·European Journal of Cancer Care·Noorazrul Yahya, Hanani A Manan
Jan 9, 2019·Frontiers in Systems Neuroscience·Sara N BurkeAndrew P Maurer
Aug 14, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G R Tabeeva
May 26, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kathleen M McAvoy, Amar Sahay
Jul 20, 2014·Psychological Research·Maria MontefineseGiorgia Committeri
Feb 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Eric W BussDaniel A Nicholson
Aug 2, 2017·Neuroscience and Biobehavioral Reviews·Desirée ColomboGiuseppe Riva
Jul 16, 2021·Frontiers in Aging Neuroscience·Yahui OuyangJianfeng Qiu
Nov 9, 2021·Frontiers in Aging Neuroscience·Yuchen LiuChun-Yi Zac Lo

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