Age-Related Changes in Pharyngeal Lumen Size: A Retrospective MRI Analysis

Dysphagia
Sonja M MolfenterC L Lazarus

Abstract

Age-related loss of muscle bulk and strength (sarcopenia) is often cited as a potential mechanism underlying age-related changes in swallowing. Our goal was to explore this phenomenon in the pharynx, specifically, by measuring pharyngeal wall thickness and pharyngeal lumen area in a sample of young versus older women. MRI scans of the neck were retrospectively reviewed from 60 women equally stratified into three age groups (20s, 60s, 70+). Four de-identified slices were extracted per scan for randomized, blinded analysis: one mid-sagittal and three axial slices were selected at the anterior inferior border of C2 and C3, and at the pit of the vallecula. Pixel-based measures of pharyngeal wall thickness and pharyngeal lumen area were completed using ImageJ and then converted to metric units. Measures of pharyngeal wall thickness and pharyngeal lumen area were compared between age groups with one-way ANOVAs using Sidak adjustments for post-hoc pairwise comparisons. A significant main effect for age was observed across all variables whereby pharyngeal wall thickness decreased and pharyngeal lumen area increased with advancing age. Pairwise comparisons revealed significant differences between 20s versus 70+ for all variables and 20s...Continue Reading

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Citations

Nov 10, 2015·Journal of the Academy of Nutrition and Dietetics·Keisuke Maeda, Junji Akagi
Oct 7, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Keisuke MaedaJunji Akagi
Aug 2, 2019·The Tohoku Journal of Experimental Medicine·Yukiko KurosawaShunsuke Minakuchi
Feb 20, 2020·Journal of Oral Rehabilitation·Ryuichiro KobuchiKazuya Takahashi
Sep 7, 2019·Dysphagia·Marie JardineJacqueline Allen
Feb 2, 2016·American Journal of Physical Medicine & Rehabilitation·Hidetaka Wakabayashi, Rimiko Uwano
Apr 25, 2018·Dysphagia·Erica G HerzbergSonja M Molfenter
Jun 13, 2018·Journal of Speech, Language, and Hearing Research : JSLHR·Sonja M MolfenterCathy Lazarus
Mar 2, 2019·The Journal of Nutrition, Health & Aging·A NaganoH Wakabayashi
May 11, 2019·Annals of Rehabilitation Medicine·Ho Young LeeSuk Hoon Ohn
May 26, 2018·Journal of Speech, Language, and Hearing Research : JSLHR·Ianessa A HumbertAlycia Rivet
Jan 11, 2019·Geriatrics & Gerontology International·Ichiro FujishimaYoshihiro Yoshimura
Jun 13, 2020·Alzheimer Disease and Associated Disorders·James C BordersNicole Rogus-Pulia
Feb 24, 2021·Dysphagia·Hidetaka WakabayashiUNKNOWN Japanese Working Group on Sarcopenic Dysphagia
Apr 28, 2021·Aging Clinical and Experimental Research·Yuta NakaoKazuhisa Domen
Jul 16, 2021·ERJ Open Research·Isabella EpiuAnna L Hudson
Jul 27, 2021·NeuroRehabilitation·Wonil KangSuk Hoon Ohn
Aug 11, 2021·Dysphagia·Ashwini M Namasivayam-MacDonaldLuis F Riquelme

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