Age-related changes in prefrontal norepinephrine transporter density: The basis for improved cognitive flexibility after low doses of atomoxetine in adolescent rats

Brain Research
Sarah E BradshawJill McGaughy

Abstract

Adolescence is a period of major behavioral and brain reorganization. As diagnoses and treatment of disorders like attention deficit hyperactivity disorder (ADHD) often occur during adolescence, it is important to understand how the prefrontal cortices change and how these changes may influence the response to drugs during development. The current study uses an adolescent rat model to study the effect of standard ADHD treatments, atomoxetine and methylphenidate on attentional set shifting and reversal learning. While both of these drugs act as norepinephrine reuptake inhibitors, higher doses of atomoxetine and all doses of methylphenidate also block dopamine transporters (DAT). Low doses of atomoxetine, were effective at remediating cognitive rigidity found in adolescents. In contrast, methylphenidate improved performance in rats unable to form an attentional set due to distractibility but was without effect in normal subjects. We also assessed the effects of GBR 12909, a selective DAT inhibitor, but found no effect of any dose on behavior. A second study in adolescent rats investigated changes in norepinephrine transporter (NET) and dopamine beta hydroxylase (DBH) density in five functionally distinct sub-regions of the prefro...Continue Reading

References

Sep 1, 1987·Journal of Microscopy·H J Gundersen, E B Jensen
Nov 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Frank P BymasterKenneth W Perry
Dec 4, 2003·Behavioural Brain Research·Kerry McAlonan, Verity J Brown
Jan 30, 2004·Clinical Therapeutics·Joshua Caballero, Milap C Nahata
Jul 15, 2004·Annals of the New York Academy of Sciences·Rudolf N CardinalBarry J Everitt
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·Jeffrey W DalleyTrevor W Robbins
Jun 14, 2005·Biological Psychiatry·Amy F T Arnsten, Bao-Ming Li
Jul 19, 2005·Annual Review of Neuroscience·Gary Aston-Jones, Jonathan D Cohen
Sep 17, 2005·Trends in Neurosciences·Sebastien Bouret, Susan J Sara
Apr 5, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zohreh Chiti, Anja G Teschemacher
Jul 6, 2007·The European Journal of Neuroscience·David S TaitTrevor W Robbins
Jul 24, 2007·Biological Psychiatry·Samuel R ChamberlainBarbara J Sahakian
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chi-Wing NgAmy Poremba
Nov 13, 2007·Journal of Shoulder and Elbow Surgery·Damian McClelland, Anastasios Paxinos
Feb 26, 2008·Child and Adolescent Psychiatric Clinics of North America·Claudia M Szobot, Oscar Bukstein
Apr 3, 2008·The American Journal of Psychiatry·Salvatore MannuzzaFrancisco X Castellanos
Dec 9, 2009·Experimental and Clinical Psychopharmacology·Amy C JanesMarc J Kaufman
Nov 26, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·B J Casey, Rebecca M Jones
Dec 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roxann C HarveyKathleen M Kantak
Mar 3, 2011·Developmental Psychobiology·Lori A Newman, Jill McGaughy
Sep 9, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Kara L AgsterBarry D Waterhouse
Sep 20, 2011·Developmental Cognitive Neuroscience·Rachel E CainJill A McGaughy
Mar 28, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Amy F T Arnsten, Katya Rubia
Nov 28, 2012·The Journal of Comparative Neurology·Kara L AgsterBarry D Waterhouse
Jul 17, 2013·Progress in Neurobiology·Andrea Bari, Trevor W Robbins
Dec 2, 2014·Journal of Physiology, Paris·María E PedreiraDaniel Tomsic
Jan 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amy C JanesScott E Lukas

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Citations

Mar 11, 2018·The Journal of Comparative Neurology·Monika J M Murphy, Ariel Y Deutch
Feb 10, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Martina Pitzer
Dec 29, 2020·Journal of Parkinson's Disease·Michael F SalvatoreVicki A Nejtek
Mar 8, 2021·Neurochemical Research·Ulyana Lalo, Yuriy Pankratov
Aug 10, 2018·European Journal of Pharmacology·Joshua A BurkEden B Maness
Mar 17, 2019·Neuropharmacology·Amélie J ReynaudFadila Hadj-Bouziane

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