Age-related changes in purinergic and adrenergic components of sympathetic neurotransmission in guinea-pig seminal vesicles

British Journal of Pharmacology
C PinnaG Burnstock

Abstract

1. Purinergic and adrenergic components of sympathetic neurotransmission and contractile responses to exogenous alpha,beta-methylene ATP and noradrenaline have been investigated in the seminal vesicles of 1-day (new-born), 2-weeks (young), 12-weeks (adult) and 2-years old (aged) guinea-pigs. 2. In seminal vesicles of new-born guinea-pigs electrical field stimulation (EFS; 80 V, 0.5 ms for 30 s, 2-32 Hz) evoked tonic frequency-related contractions. In 2-weeks old guinea-pigs the tonic contraction masked an initial phasic component of the neurogenic responses, whereas in 12-weeks and 2-years old guinea-pigs, neurogenic responses were biphasic, a phasic response being followed by a tonic contraction. In all experimental groups, prazosin (10(-6) M) blocked the tonic contraction while desensitization of P2X receptors by alpha,beta-methylene ATP (10(-4) M) abolished the phasic responses. 3. The phasic purinergic component of the neurogenic response was significantly higher in 12-weeks and 2-years old animals, compared with 2-weeks old guinea-pigs. At 32 Hz phasic contractions were (mN mg(-1) tissue): 0.047+/-0.012, 0.018+/-0.040 and 0.147+/-0.026 in 2-weeks, 12-weeks and 2-years old guinea-pigs, respectively. In contrast, the tonic a...Continue Reading

References

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Citations

Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·James R Docherty
Nov 26, 2013·Purinergic Signalling·Geoffrey Burnstock
May 20, 2015·Autonomic Neuroscience : Basic & Clinical·George I Gorodeski
May 21, 2015·Purinergic Signalling·Geoffrey Burnstock, Nicholas Dale
Jan 28, 2006·European Journal of Pharmacology·Manuela MoratoAntónio Albino-Teixeira
Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·C E HillS L Sandow
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock

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