Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration

Neurobiology of Aging
George T KannarkatMalú G Tansey

Abstract

Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the regulator of G-protein signaling-10 (RGS10) locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in the RGS10-null mice induces nigral dopaminergic (DA) degeneration, suggesting that RGS10 modulates neuroimmune interactions and may influence susceptibility to neurodegeneration. Because age is the strongest risk factor for neurodegenerative disease, we assessed whether RGS10 expression changes with age and whether aged RGS10-null mice have altered immune cell profiles. Loss of RGS10 in aged mice does not alter the regulation of nigral DA neurons but does alter B-cell, monocyte, microglial, and CD4+ T-cell populations and inflammatory cytokine levels in the cerebrospinal fluid. These results suggest that loss of RGS10 is associated with an age-dependent dysregulation of peripheral and central immune cells rather than dysregulation of DA neuron function.

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Citations

Feb 3, 2016·Journal of Neuroinflammation·Jae-Kyung LeeMalú G Tansey
May 24, 2017·Cellular and Molecular Neurobiology·John Alimamy KabbaTao Pang
Feb 6, 2020·Molecular Pharmacology·Katelin E Ahlers-DannenRory A Fisher
Jan 11, 2020·Computational and Structural Biotechnology Journal·Paula Santos-OtteStuart Maudsley
Jul 29, 2021·Science Signaling·Ivan K ChinnKirk M Druey

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