PMID: 2113545Jun 1, 1990Paper

Age-related changes in sucrase and lactase activity in the small intestine of 3- and 10-week-old obese mice (C57BL/6Jobob)

Journal of the American College of Nutrition
C FloresO Koldovsky

Abstract

The relationship between obesity and the digestion of carbohydrates is poorly understood. Data in humans have provided conflicting results. Studies using the obese mouse (C57BL/6Jobob) suggest that obesity is associated with increased activity of intestinal alpha-disaccharidases. To evaluate the developmental pattern of these enzyme activities in obesity, we determined the activity of sucrase and lactase in the small intestine of genetically obese mice (C57BL/6Jobob) and lean littermates at 3 and 10 weeks of age. Sucrase and lactase activities were measured on intestinal homogenates from segments of the small intestine in mice maintained on standard laboratory diets during the postweaning period. Results were expressed as specific activity and total activity per intestinal segment. Obese mice did not differ from lean littermates in body weight at 3 weeks of age, but exhibited increased protein content in the proximal small intestine. Sucrase specific activity was significantly higher in the obese mice at 3 weeks of age in all intestinal segments. Sucrase total activity showed a similar pattern. At 10 weeks of age, body weights of obese mice were substantially greater than the lean littermates. Sucrase specific and total activit...Continue Reading

References

Jun 1, 1979·Metabolism: Clinical and Experimental·P U Dubuc, P L Willis
Sep 10, 1976·European Journal of Clinical Investigation·B M IversenJ H Solhaug
Jun 1, 1975·The American Journal of Clinical Nutrition·E LebenthalH Shwachman
Jan 1, 1986·Journal of the American College of Nutrition·C A FloresO Koldovský
Oct 1, 1974·The American Journal of Physiology·M L Kaplan, G A Leveille
Feb 1, 1967·The Journal of Clinical Investigation·J J DerenN Zamcheck
Jan 1, 1983·Annals of Nutrition & Metabolism·P J Hanson, A P Morton
Mar 1, 1980·The American Journal of Physiology·P MedaL Orci
Apr 1, 1963·Canadian Journal of Biochemistry and Physiology·D G BLAIRJ TUBA
Jan 1, 1964·Analytical Biochemistry·A DAHLQVIST

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Citations

Mar 28, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D F PinheiroM L M Vicentini-Paulino

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