Age-related changes in the expression of Alzheimer's beta APP in the brain of senescence accelerated mouse (SAM)-P/10

Neuroreport
S J JeongY H Suh

Abstract

Patients with Alzheimer's disease (AD) show loss of memory and cognitive deficits the molecular mechanisms of which are not completely known. We examined age-related changes in the expression levels of beta-amyloid precursor protein (beta APP) in the brain of the senescence accelerated mouse (SAM) P/10, which shows age-dependent brain atrophy and impairment in learning and memory, and in the senescence resistant mouse (SAM)-R/1 using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot. Levels of both beta APP mRNA and protein increased with age, reaching a peak at 8 months of age in the hippocampus of SAM-P/10. In contrast, beta APP protein level decreased with age in the hippocampus of SAM-R/1 while beta APP mRNA level did not change significantly. Levels of beta APP mRNA and protein showed no change with ageing in other brain regions, including cerebral cortex, thalamus/midbrain and cerebellum brain stem. These results suggest that the beta APP over-expression in the hippocampus might be related to the characteristic memory loss in SAM-P/10.

References

Sep 1, 1991·Journal of the American Geriatrics Society·T TakedaK Higuchi
Aug 1, 1989·Archives of Neurology·F Lai, R S Williams
Sep 1, 1994·Journal of Neuropathology and Experimental Neurology·D J Selkoe
Jan 1, 1993·Progress in Brain Research·K Abe, K Kogure

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Citations

Sep 18, 2004·Trends in Neurosciences·Bruce Teter, Caleb E Finch
Nov 1, 2005·Ageing Research Reviews·Theresa Joseph Kannanayakal, James Eberwine
Oct 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Hindupur K Anandatheerthavarada, Latha Devi

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