Age-related changes in the NMDA receptor/nitric oxide/cGMP pathway in the hippocampus and cerebellum of freely moving rats subjected to transcerebral microdialysis

The European Journal of Neuroscience
F Vallebuona, M Raiteri

Abstract

The N-methyl-D-aspartate (NMDA) receptor/nitric oxide synthase/guanylate cyclase pathway was studied during aging by monitoring extracellular cGMP in the rat hippocampus and cerebellum during in vivo microdialysis. In the hippocampus the basal cGMP efflux decreased by 50% from 3 to 12 months of age, whereas it remained constant with age in the cerebellum. Locally perfused NMDA (1 mM) evoked remarkable cGMP responses in 3-month-old rats; in the hippocampus the cGMP production was already dramatically reduced at 12 months, whereas in the cerebellum a similar impairment occurred much later (24 months). The nitric oxide donor S-nitroso-N-penicillamine (1 mM) elicited cGMP responses which slightly decreased from 3 to 12-24 months in the hippocampus, while no significant decrement with age could be seen in the cerebellum. Local perfusion of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX, 1 mM) produced large increases in hippocampal cGMP levels. The response decreased at 12 and 24 months, apparently in parallel with the fall in the basal level of cGMP. No significant differences across ages were observed following IBMX infusion in the cerebellum. The decreases in basal outflow and in the NMDA-evoked cGMP response s...Continue Reading

References

Sep 1, 1978·Neuropharmacology·L H GreenbergB Weiss
Mar 1, 1991·Neurobiology of Aging·G L WenkL C Cork
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T J O'DellO Arancio
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Jul 9, 1991·European Journal of Pharmacology·G A BöhmeJ C Blanchard
Oct 17, 1989·European Journal of Pharmacology·J GarthwaiteS Moncada
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G KnowlesS Moncada
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jan 1, 1989·Annual Review of Neuroscience·M Ito
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Aug 18, 1993·Biochimica Et Biophysica Acta·H H SchmidtU Walter
Jan 7, 1993·Nature·T V Bliss, G L Collingridge

❮ Previous
Next ❯

Citations

Mar 10, 2010·Molecular Neurobiology·Katarzyna Urszula Domek-Łopacińska, Joanna B Strosznajder
Dec 10, 2002·Neurochemistry International·Henryk JeskoJoanna B Strosznajder
May 13, 1999·Progress in Neurobiology·E Fedele, M Raiteri
Feb 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A BhardwajR C Koehler
Feb 17, 1998·The European Journal of Neuroscience·M A Baltrons, A García
Feb 3, 1999·Annals of the New York Academy of Sciences·R C MeyerD K Ingram
Jun 5, 2012·Journal of Neuroscience Methods·Niall J FinnertyJohn P Lowry
Aug 5, 2008·Neuropharmacology·F Josef van der StaayMartin Hendrix
Feb 19, 2005·Neurobiology of Aging·Cristoforo ScavoneRegina Pekelmann Markus
Jul 12, 2005·Brain Research. Developmental Brain Research·K Domek-ŁopacińskaJ de Vente
Jun 18, 2016·Frontiers in Physiology·Paula F KinoshitaCristoforo Scavone
Nov 26, 1998·Microscopy Research and Technique·K Yamada, T Nabeshima
Feb 14, 2012·The Journal of Pharmacology and Experimental Therapeutics·Robin J KleimanChristopher J Schmidt
Aug 22, 2014·Medical Science Monitor Basic Research·Ipek Komsuoglu CelikyurtFeyza Aricioglu
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A BhardwajR C Koehler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.