PMID: 9165298Jan 1, 1997Paper

Age-related changes in the peroxyl radical scavenging capacity of human plasma

Free Radical Biology & Medicine
R T AejmelaeusH Alho

Abstract

Aging and the diseases that typically follow with increasing age, notably atherosclerosis and cancer, are often proposed to be involved in increased oxidative stress. Animal studies, on the other hand, show no clear-cut pattern of age-related changes in enzymatic antioxidant defences. In this study we have demonstrated that total peroxyl radical scavenging antioxidant capacity (TRAP) in human plasma changes with age. We also found that among the antioxidants in human plasma there exists a major fraction of so far unidentified antioxidant(s). A chemiluminescent TRAP assay was used to determine the presence of peroxyl radical scavenging antioxidants in human plasma. The material consisted of 87 healthy volunteers, aged 20-96 years, who used no regular medication, vitamins, or trace elements. In females, total antioxidant capacity increased significantly during the life span. The increase in TRAP was mainly due to unidentified antioxidants. In males, TRAP increased until age 51-74, and then significantly decreased. The decrease observed among males was also due to the sharp decline in the concentration of unidentified antioxidants.

References

Jan 1, 1992·Free Radical Research Communications·E LissiM D Del Castillo
Jan 1, 1990·Experimental Gerontology·R S Sohal, R G Allen
Apr 30, 1990·Mechanisms of Ageing and Development·R S SohalU T Brunk
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Feb 15, 1987·The Biochemical Journal·K Karlsson, S L Marklund
Jul 1, 1986·Age and Ageing·A NissinenS Punsar
Jun 1, 1982·Annals of the Rheumatic Diseases·S Akizuki
Jun 30, 1995·Mechanisms of Ageing and Development·R S SohalB H Sohal
Jan 1, 1994·Methods in Enzymology·C Rice-Evans, N J Miller
Sep 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·T AdachiK Hirano
Feb 1, 1994·Free Radical Biology & Medicine·N W KooyJ S Beckman
Jun 1, 1993·Free Radical Biology & Medicine·B F Becker
Feb 1, 1993·Aging : Clinical and Experimental Research·R S Sohal
Jul 1, 1956·Journal of Gerontology·D HARMAN
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN

❮ Previous
Next ❯

Citations

Mar 11, 2008·Molecular Biotechnology·Olfa ChehabKacem Mahdouani
May 5, 2001·Mechanisms of Ageing and Development·V M Mendoza-NúñezM A Altamirano-Lozano
Jun 12, 1999·Mechanisms of Ageing and Development·V M Mendoza-NuñezM A Altamirano-Lozano
Dec 21, 2002·The Science of the Total Environment·Maria PizzichiniLuciano Fonzi
Dec 21, 2000·Free Radical Biology & Medicine·A GhiselliC Scaccini
Jan 21, 2000·Free Radical Biology & Medicine·R L Prior, G Cao
Oct 29, 2005·European Journal of Clinical Nutrition·M Andriollo-SanchezA M Roussel
Mar 3, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·José L QuilesJosé Mataix
Mar 23, 2006·Pancreas·Waldemar SajewiczStanisław Nabzdyk
Oct 22, 2009·Redox Report : Communications in Free Radical Research·Oluseye A OyawoyePaul Hardiman
Nov 30, 2004·American Journal of Veterinary Research·Zlatko PavlicaUros Skaleric
Apr 14, 2016·Biological Research·Yosra SouidenKacem Mahdouani
Oct 24, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·F VegliaV Cavalca
Dec 14, 2004·Environmental Research·Martha A Sánchez-RodríguezVíctor Manuel Mendoza-Núñez
May 5, 2012·Schizophrenia Research·Xiang Yang ZhangThomas R Kosten
May 23, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·C NälsénB Vessby
Oct 1, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·David OlivierThierry Patrice
Nov 30, 2005·Archives of Medical Research·Gilberto L Pardo-AndreuRené Delgado
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·J S LeinonenH Alho
Mar 23, 2006·Free Radical Research·Lizette GilTilman Grune
Nov 9, 2006·Free Radical Research·Peter Voss, Werner Siems
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Andy W C ManNing Xia
Feb 18, 2019·American Journal of Ophthalmology·Carla J Siegfried, Ying-Bo Shui
May 23, 2001·Archives of Biochemistry and Biophysics·P EvelsonE A Lissi
Feb 20, 2003·Journal of Agricultural and Food Chemistry·Chi-Tai Yeh, Gow-Chin Yen
Jan 27, 2009·Clinics in Dermatology·Umberto Cornelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.