Age-related changes in tissue and plasma zinc levels: modulation by exogenously administered melatonin

Experimental Aging Research
Güler OztürkLale Afrasyap

Abstract

Melatonin (MEL) is synthesized mainly in the pineal gland and derived from 5-hydroxytryptophan (5-HTP). Zinc (Zn) is one of the most important trace elements in the body. Zn and MEL levels are changed with aging. The aim of this study was to investigate the age-related changes of tissue and plasma Zn levels and effect of MEL administration on these parameters. Male wistar rats received for 3 weeks subcutaneous injection of MEL (10 mg/kg). Kidney and pancreas Zn levels in old rats were significantly lower than middle-aged group. Spleen, small intestine, and plasma Zn levels were not different in middle-aged and old rats. On the other hand, MEL treatment increased Zn levels of small intestine and plasma in middle-aged rats. However, kidney, spleen, and pancreas Zn levels were unaffected by MEL treatment.

References

Jan 1, 1979·World Review of Nutrition and Dietetics·J M Hsu
Sep 1, 1992·Neuroendocrinology·G P TrentiniA D Genazzani
Jan 1, 1991·Annals of the New York Academy of Sciences·W PierpaoliW Regelson
Jan 1, 1991·Annals of the New York Academy of Sciences·N FabrisM Provinciali
Feb 1, 1989·Biological Psychiatry·D R Thomas, A Miles
Feb 1, 1986·Biological Psychiatry·N P NairJ X Thavundayil
Dec 19, 1980·Science·R J ReiterD T Dinh
Jan 1, 1995·Journal of Pineal Research·R J ReiterD Acuña-Castroviejo
May 31, 1994·Annals of the New York Academy of Sciences·E MocchegianiN Fabris
May 31, 1994·Annals of the New York Academy of Sciences·N Fabris
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·W Pierpaoli, W Regelson
Feb 1, 1997·European Journal of Clinical Nutrition·C FortesS Ebrahim
Jan 1, 1997·Life Sciences·R ReiterA Muñoz-Hoyos
Jan 8, 2000·Journal of Pineal Research·D L DrazenR J Nelson
Jun 5, 2002·Mechanisms of Ageing and Development·Russel J ReiterSusanne Burkhardt
Mar 11, 2004·Journal of Pineal Research·Jolanta JaworekWiesław W Pawlik
Nov 16, 2004·Toxicology and Applied Pharmacology·Sohair A Moustafa

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