Age-related changes in total arterial capacitance from birth to maturity in a normotensive population

Hypertension
G de SimoneR B Devereux

Abstract

We evaluated the effect of body growth and aging on the ratio of echocardiographic (Teichholz) stroke volume to pulse pressure (SV/PP ratio) in 373 normal-weight, normotensive children to adolescents (1 day to 17 years old; 166 girls, 87 nonwhite) and 393 normal adults (17 to 85 years old; 164 women, 112 nonwhite). Stroke volume increased with age in children (r = .64, P < .0001) and was stable in adults; pulse pressure decreased slightly with age in children (r = -.10, P = .06) and increased in adults (r = .29, P < .0001). As a consequence, SV/PP ratio increased with age in children (r = .51, P < .0001) and decreased in adults (r = -.18, P = .0004). To control for changes in body size that influence the size of the arterial tree, we used ANCOVA to adjust SV/PP for body size. Body size-adjusted SV/PP ratio was no longer related to age in children, whereas the negative relation with aging in adults remained statistically significant (r = -.19, P < .0002). Heart rate was negatively related to SV/PP ratio in both children and adolescents and adults, but this relation did not influence the relation with age. In multivariate analysis, high SV/PP ratio was predicted by greater height (P < .002) and weight (P < .04) and nonwhite race ...Continue Reading

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References

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Citations

Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J H HenriksenS Møller
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesco SalernoLarry Burdick
Mar 31, 2009·Journal of Hypertension·Giovanni de SimoneOreste de Divitiis
Jun 1, 2012·Annals of Biomedical Engineering·Orestis VardoulisNikolaos Stergiopulos
May 21, 2014·American Journal of Hypertension·Melissa C CaugheyAlan L Hinderliter
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Jul 27, 1999·Journal of Hypertension·G de SimoneM J Roman
Jun 21, 2001·The American Journal of Geriatric Cardiology·Michael D. VanAuker
Feb 1, 2002·Journal of Hypertension·Giovanni de SimoneRichard B Devereux
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Lin ZhouXirong Liu
Feb 25, 2011·Journal of Hypertension·Pascal RossiAnna A Ahimastos
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Apr 28, 2017·Clinical and Experimental Hypertension : CHE·Atsushi NakagomiYoshio Kobayashi
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