Age-related changes in vascular responses to angiotensin-(1-7) in female mice

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Fabiana P Costa-FragaRafaela F da Silva

Abstract

The vasodilatory effect of angiotensin-(1-7) seems to vary between sexes, and estradiol (E2) can modulate the magnitude of the Ang-(1-7) vasodilatory response in female rats. However, there are few studies addressing the influence of sex on the age-related vasodilatory effect of Ang-(1-7). Here, we evaluated the vasodilatory response to Ang-(1-7) on vascular ageing. Ang-(1-7) dose-response curves were determined in mice aortic rings from males (old and young) and females (E2 treated/non-treated old and young) mounted in an isolated organ chamber. Abdominal aortic rings were used for protein expression analysis and determination of reactive oxygen species (ROS) and nitric oxide (NO) production. Our results showed that the Ang-(1-7) vasodilatory effect was absent in aorta from old females, contrasting with a full response in vessels from young females. The Ang-(1-7) vasodilatory effect was restored by E2 replacement in old females. A robust increase in Mas receptor, SOD2, NRF-2 and NOX2 expression was observed in aorta from old females, which was normalized by E2. This effect of E2 was also associated with lower production of ROS and normal levels of NO. In conclusion, our data demonstrated that pathways involved in the Ang-(1-7)...Continue Reading

References

Jul 9, 1998·Journal of Human Hypertension·K ManhemA Svensson
Jan 12, 1999·The Journal of Physiology·G VaccaN Surico
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M M ThompsonS Anderson
Sep 4, 2003·Hypertension·E Ann Tallant, Michelle A Clark
Dec 5, 2003·Journal of Hypertension·Angelo ScuteriJerome L Fleg
Dec 26, 2006·Journal of Hepatology·Regina Maria PereiraAna Cristina Simões e Silva
Jul 14, 2010·European Journal of Pharmacology·Luciano S A CapettiniVirginia S Lemos
Feb 9, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·A H E M Maas, Y E A Appelman
Jan 31, 2012·Current Pharmaceutical Design·Luciano S A CapettiniRafaela F da Silva
Mar 31, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Manisha GupteLisa A Cassis
Jun 12, 2012·Frontiers in Physiology·Susana NovellaCarlos Hermenegildo
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jul 16, 2013·Free Radical Biology & Medicine·Mariam El AssarLeocadio Rodríguez-Mañas
Mar 26, 2014·Hypertension·Robson Augusto Santos
Sep 12, 2014·Histochemistry and Cell Biology·María Gabriela MoralesClaudio Cabello-Verrugio
Mar 27, 2015·Clinical and Experimental Pharmacology & Physiology·Maximilian I Pinkham, Carolyn J Barrett
Nov 19, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M V BorgoG R Abreu
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Oct 3, 2017·Aging and Disease·Xianglai XuKunlin Jin
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos

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Citations

Apr 30, 2020·Geriatrics & Gerontology International·Masaki Mogi
Aug 30, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Daniela MedinaAmy C Arnold
Sep 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Maureen CzickRobert Shapter
Jul 24, 2020·International Journal of Molecular Sciences·Amanda J MillerAmy C Arnold
Jul 8, 2021·Journal of Human Hypertension·Paul J ConnellyChristian Delles

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Methods Mentioned

BETA
electrophoresis
hormone replacement therapy

Software Mentioned

GraphPad Prism
ImageJ
Windaq

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