Age-related changes of bone mineral density and microarchitecture in miniature pigs

The Journal of Veterinary Medical Science
Azusa InuiKoichi Mamba

Abstract

Bone mineral density (BMD), distribution of its density and bone histomorphometric parameters were evaluated in lumbar vertebra of normally growing miniature pigs. The fourth lumbar vertebra (L4) of the Göttingen miniature pig were used in this cross-sectional study in vitro. The BMD of the miniature pig was similar to that of humans in tendency of gender differences and some growth patterns during puberty. In these regards this animal appears useful as a model for human bone study. However, the trabecular and cortical BMDs of lumbar spine were extremely high value (399.43 +/- 26.36 mg/cm(3) in female trabeculae; 973.06 +/- 69.55 mg/cm(3) in female cortical bone; 419.04 +/- 34.84 mg/cm(3) in male trabeculae; 1038.81 +/- 125.72 mg/cm(3) in male cortical bone in pigs 30 months or more). Furthermore, histomorphometric analysis yielded values that were remarkably different from those found in humans. From these results, it was revealed that miniature pig had a higher bone mass and denser trabecular network than human, indicating that its bone is probably stronger. Therefore, care should be taken in choosing the miniature pig as a bone study model.

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Citations

Oct 21, 2011·Journal of Biomechanical Engineering·Dominic BoisclairYvan Petit
Feb 3, 2016·Clinical Implant Dentistry and Related Research·Bo WenZhiyu Cai
May 29, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Susan Reinwald, David Burr
May 17, 2013·Journal of Biomechanics·Ramin RasoulianIwona Jasiuk
Sep 13, 2016·Current Molecular Biology Reports·Christoph RückerHeike Walles
Dec 5, 2019·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Philippa BowlandLouise M Jennings
Apr 27, 2021·PloS One·Raelene M CowieLouise M Jennings

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