PMID: 15374497May 1, 1990Paper

Age-related changes of glutamate dehydrogenase in the rat hippocampus: an enzyme histochemical study

Archives of Gerontology and Geriatrics
E BronzettiF Amenta

Abstract

Enzyme histochemical techniques associated with microphotometry were used to evaluate the reactivity of glutamate dehydrogenase (GDH) in the hippocampus of young (3 month) adult (12 month) and old (26 month) male Sprague-Dawley rats. In young rats the highest level of enzymatic reactivity was found in the stratum oriens of the CA-1-CA-4 fields followed in descending order by the molecular layer of fascia dentata, and by the layer of mossy fibers. In all the layers investigated GDH reactivity was higher in adult that in young rats. The older animals exhibited lower GDH reactivity than adult rats in almost all of the layers and higher enzymatic reactivity than in young rats in the stratum oriens of the CA-1-CA-4 fields. The hippocampus is known to be involved in the acquisition of two-way avoidance learning and is thought to utilize glutamate as one of its main neurotransmitters. These data suggest a possible relationship between hippocampal glutamatergic transmission and impairment of acquisition of avoidance learning occurring with age. Moreover, the possibility that a decreased glutamate catabolism occurring in old rats may contribute to the neuronal loss described in the hippocampus of aged rats is discussed.

References

Jan 1, 1977·Experimental Aging Research·M C McNamaraA T Miller
Sep 1, 1988·Mechanisms of Ageing and Development·E BronzettiF Amenta
Nov 1, 1987·Mechanisms of Ageing and Development·F Ferrante, F Amenta
Jan 1, 1972·Developmental Psychobiology·G J Egger, P J Livesey
Oct 1, 1967·Journal of Neurochemistry·K L Reichelt, E Kvamme
Jun 1, 1966·Psychological Bulletin·W VogelJ G Draguns
Aug 1, 1970·Journal of Neurochemistry·C Blomstrand, A Hamberger
Jan 1, 1967·Zeitschrift für Zellforschung und mikroskopische Anatomie·S I Mellgren, T W Blackstad
May 25, 1966·Biochemical and Biophysical Research Communications·C J Van den BergH Waelsch
Jan 1, 1981·Neurobiology of Aging·G E GibsonJ Sansone
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L A MamounasM Baudry
Feb 1, 1981·Pharmacology, Biochemistry, and Behavior·W J Freed, R J Wyatt
May 1, 1980·Mechanisms of Ageing and Development·I F de Koning-Verest
Feb 1, 1976·Neurochemical Research·N Seiler, G Wagner

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Citations

Dec 31, 1991·Mechanisms of Ageing and Development·F AmentaW L Collier

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