PMID: 9431847Feb 12, 1998Paper

Age-related changes of the mechanical properties of the carotid artery in spontaneously hypertensive rats

Journal of Hypertension
A ZanchiD Hayoz

Abstract

We had previously demonstrated that the distensibility of the carotid artery in spontaneously hypertensive rats (SHR) aged 18 weeks does not differ from that of the carotid artery in normotensive animals for common pressure levels, despite vascular hypertrophy in SHR. To examine the time-course effects of hypertension on the geometry and the mechanical properties of the carotid artery in SHR. The mechanical behavior of the carotid arteries of anesthetized SHR, stroke-prone SHR (SHRSP), and Wistar-Kyoto (WKY) rats aged 4, 8, 12, 16, and 32 weeks was examined by simultaneously measuring the internal diameter with an A-mode ultrasonic echo-tracking device and the intra-arterial pressure with a computerized data-acquisition system. Histometric measurements of the carotid artery were performed after death of rats. Blood pressure increased with time in rats of the two genetic hypertensive models. However, it rose earlier and to higher levels in the SHRSP. Cardiac hypertrophy was comparable in the two hypertensive groups whereas vascular hypertrophy was less pronounced in the SHRSP than it was in the SHR. There was an age-related decrease in arterial distensibility in rats of all groups that was more pronounced in the SHRSP than it wa...Continue Reading

References

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Citations

May 16, 2009·Current Hypertension Reports·François FeihlBernard Waeber
Mar 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natacha SlobodaAthanase Benetos
Mar 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Harald M StaussMichael G Anderson
Sep 29, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Emma L BaileyJoanna M Wardlaw
May 29, 2016·Physiological Reports·George LindesayChristine Vayssettes-Courchay
Nov 17, 2001·Hypertension·G CohuetP Lacolley
Nov 5, 2016·Journal of Biomechanical Engineering·Stephanie A PasquesiSusan S Margulies
Oct 26, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Carlos LabatPatrick Lacolley
Jan 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Emmanuel CossonHubert Dabire
May 6, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Motoyuki IemitsuTakashi Miyauchi
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes
May 4, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Mary Osborne-PellegrinPatrick Lacolley

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