Age-Related Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction

Journal of the American College of Cardiology
Jasper TrompJohn J V McMurray

Abstract

Although heart failure with preserved ejection fraction (HFpEF) is considered a disease of the elderly, younger patients are not spared from this syndrome. This study therefore investigated the associations among age, clinical characteristics, and outcomes in patients with HFpEF. Using data on patients with left ventricular ejection fraction ≥45% from 3 large HFpEF trials (TOPCAT [Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function], I-PRESERVE [Irbesartan in Heart Failure With Preserved Systolic Function], and CHARM Preserved [Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity]), patients were categorized according to age: ≤55 years (n = 522), 56 to 64 years (n = 1,679), 65 to 74 years (n = 3,405), 75 to 84 years (n = 2,464), and ≥85 years (n = 398). This study compared clinical and echocardiographic characteristics, as well as mortality and hospitalization rates, mode of death, and quality of life across age categories. Younger patients (age ≤55 years) with HFpEF were more often obese, nonwhite men, whereas older patients with HFpEF were more often white women with a higher prevalence of atrial fibrillation, hypertension, and chronic kidney diseas...Continue Reading

Citations

Sep 24, 2019·Clinical Pharmacology and Therapeutics·Sophie Van Linthout, Carsten Tschöpe
Dec 5, 2019·European Heart Journal·Carolyn S P LamAdriaan A Voors
Jul 6, 2020·Current Hypertension Reports·Karnika AyinapudiSuzanne Oparil
Sep 18, 2020·Journal of Cardiovascular Medicine·Adrianne CasebeerThomas Evers
Jan 14, 2021·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·A UijlA W Hoes
Feb 21, 2021·Cardiovascular Diabetology·Sibille LejeuneAnne-Catherine Pouleur
Feb 23, 2020·Journal of the American College of Cardiology·Valentin Fuster
Feb 10, 2020·JACC. Heart Failure·Jasper TrompIziah E Sama
Mar 25, 2021·BMJ : British Medical Journal·Jasper TrompJennifer E Ho
May 8, 2021·The Journal of Clinical Hypertension·Anping CaiYingqing Feng
May 31, 2021·Heart Failure Clinics·Andrea SalzanoAlberto M Marra
May 31, 2021·Heart Failure Clinics·Hidemi SorimachiBarry A Borlaug
Feb 17, 2021·The Journal of Cardiovascular Nursing·Kavita RadhakrishnanLinda Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.