Age-related characteristics of cutaneous melanoma in a Spanish Mediterranean population

International Journal of Dermatology
Iria MonteroE Nagore

Abstract

Melanoma is considered a heterogeneous tumor with genetic and environmental factors involved in its pathogenesis. The impact of these factors varies depending on age. The aim of this study was to characterize the epidemiological, phenotypic, and histological features of patients with melanoma according to three age groups: ≤40, 41-65, and >65 years. A total of 1122 consecutive patients with invasive melanoma definitively treated in our institution since January 2000 were selected from our melanoma database. Epidemiological, phenotypic, and histological data were retrieved and analyzed as a function of age. Female patients predominated in the younger age group. The location of cutaneous malignant melanoma differed with age. In the younger and middle age groups, tumors presented mainly on the trunk, while in the older group they were mainly found on the head/neck. Signs of actinic damage such as actinic keratoses, solar lentigines, or other skin tumors increased with age, while genetic factors such as family history of melanoma or a high number of common melanocytic nevi were more frequent in the younger group. Our results suggest that melanoma development in younger patients is the result of genetic factors, particularly related...Continue Reading

References

Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F R de Gruijl
May 22, 2002·Archives of Dermatology·Alexander J ChamberlainJohn W Kelly
Nov 28, 2002·Annals of Surgery·Detlef K BartschHarald Rieder
Mar 5, 2004·The British Journal of Dermatology·M B Lens, M Dawes
Nov 3, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Esther de Vries, Jan Willem Coebergh
Jan 20, 2005·The British Journal of Dermatology·C S MurrayV R Doherty
Jun 11, 2005·Cancer Causes & Control : CCC·Victor SiskindAdèle C Green
Aug 30, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Jan 5, 2008·International Journal of Dermatology·William TingHobart W Walling
Jul 26, 2008·Annals of Epidemiology·Leslie K DennisJulie A Coughlin
Sep 2, 2008·Cancer Causes & Control : CCC·Eduardo NagoreCarlos Guillén
Jul 1, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·E NagoreC Guillen
Jul 7, 2009·Nature Genetics·D Timothy BishopJulia A Newton Bishop
Dec 4, 2010·International Journal of Cancer. Journal International Du Cancer·Patricia F WilliamsDavid C Whiteman
Apr 7, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·C BarbeF Grange
Jun 29, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·A JuzenieneJ Moan
Jun 30, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·B KøsterH Clemmensen
Nov 2, 2011·Journal of the American Academy of Dermatology·Ahmedin JemalPhyllis A Wingo
Nov 2, 2011·Journal of the American Academy of Dermatology·Hannah K WeirDonatus U Ekwueme
Nov 19, 2011·International Journal of Cancer. Journal International Du Cancer·Anne E CustMark A Jenkins
Feb 14, 2012·Pigment Cell & Melanoma Research·John R DaviesJulia Newton-Bishop
May 26, 2012·Actas dermo-sifiliográficas·I BallesterE Nagore

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Citations

Aug 16, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·C BaykalN Buyukbabani
Oct 21, 2016·Journal of Translational Medicine·Sarah A WeissJudy Zhong
Dec 13, 2017·Oncotarget·Alejandro Martin-GorgojoEduardo Nagore

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