PMID: 11902317Mar 21, 2002Paper

Age-related clinical and neurophysiologic characteristics of intractable epilepsy associated with cortical malformation

Epilepsia
K KobayashiEiji Oka

Abstract

To elucidate the relationship between the characteristics of cortical malformation (CM) and those of associated epilepsy, and also to investigate the prognostic value of the clinical and magnetic resonance imaging (MRI) findings for the seizure and mental outcome. We studied 41 patients with CM and epilepsy, and the patients were divided according to the age at onset of epilepsy into two groups: one group of 15 patients with very early onset before age 3 months, and the other group of 26 patients with onset at 3 months or later. Statistical relationship was examined between the types of dysplastic lesions demonstrated by MRI and the age at onset of epilepsy. The effects of the onset age and the features of CM on the outcome of seizures and mental or developmental state also were analyzed. The very early-onset epilepsy was related to the dysplastic patterns of reduced sulci and blurred cortical-subcortical junction, which suggested focal CM, whereas the later-onset epilepsy was related to polymicrogyria. The age at onset of epilepsy was related to the poor seizure outcome, and both the onset age and wide distribution of CM were related to severe retardation. The type of CM influences the expression of associated epilepsy, especi...Continue Reading

Citations

Oct 24, 2007·Neuropsychology Review·Chris E Morrison, Luba Nakhutina
Jan 11, 2008·Epilepsia·F Irsel TezerSerap Saygi
May 17, 2011·Epilepsia·Kati RantanenPirkko Nieminen

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