PMID: 3745810Sep 1, 1986Paper

Age-related decline in ligand-induced actin polymerization in human leukocytes and platelets

Journal of Gerontology
K M Rao

Abstract

The change in monomeric actin was measured in human polymorphonuclear leukocytes (PMN) and platelets, using the DNase I inhibition assay, after stimulation with various agents. PMN were stimulated with the chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (FMLP) in 199 donors, the tumor promoter phorbol myristate acetate in 112 donors, and the hormones tri-iodothyronine and phenylephrine, in 118 donors. The donors ranged in age from 20 to 89 years. A decrease in ligand-induced actin polymerization was detected in PMN obtained from the older population, on stimulation with FMLP (p = .014) and PMA (p = .0038). In platelets stimulated with thrombin (163 donors) a significant decrease in actin polymerization also was noted in the older group (p = .017). In addition, in platelets actin polymerization was less in women compared with men (p = .042). Because actin polymerization is an event that might have an important role in cellular activation, the age-related decline in the physiological functions might be related to a decrease in ligand-induced actin polymerization.

Citations

Nov 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S I Rattan, A Derventzi
Jan 1, 1990·Experimental Gerontology·K M Rao, H J Cohen
Mar 1, 1991·Mutation Research·A Derventzi, S I Rattan
Aug 21, 2001·Mechanisms of Ageing and Development·J M LordM Salmon
Apr 26, 2003·Mechanisms of Ageing and Development·Anja Kristina Schröder, Lothar Rink
Oct 14, 2008·Rejuvenation Research·Carl F FortinTàmàs Fülöp
Jul 28, 2009·Mechanisms of Ageing and Development·Thorsten PetersKarin Scharffetter-Kochanek
Jul 1, 2008·Experimental Gerontology·Christian R GomezElizabeth J Kovacs
Aug 6, 2005·International Journal of Cardiology·Masaharu IshiharaTomohiko Kisaka
Mar 25, 2004·Journal of Leukocyte Biology·Timothy P PlackettElizabeth J Kovacs
Jun 4, 2019·Clinical Hemorheology and Microcirculation·A KuhnlaF Jung
Feb 14, 1992·Biochemical and Biophysical Research Communications·A DerventziB F Clark

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