Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys.

Journal of Neural Transmission
Feng YuePiu Chan

Abstract

Advanced human aging is associated with progressive declines of motor function and a risk factor for Parkinson's disease, which mainly involves central nigrostriatal dopaminergic system. The present study investigated age-related changes in motor behaviors and alterations of the number of nigrostriatal dopaminergic terminals in non-human primates. A total of 30 cynomolgus monkeys (Macaca fascicularis) of age 3.5-15.5 years were studied. Motor behaviors including upper limb movement time and the amount of overall home cage activity were quantitatively assessed using a modified movement assessment panel and a newly developed webcam-based monitoring system. The function of the dopaminergic system was semi-quantitatively measured by (99m)Tc-TRODAT-1 uptake rates, a dopamine transporter (DAT) specific radiopharmaceutical with SPECT imaging. The results showed a significant decline in motor behaviors associated with aging which were significantly correlated with age-related decreases of (99m)Tc-TRODAT-1 uptake. A further partial correlation analysis independent of age indicated that age contributed to the relationship between striatal DAT levels and motor behaviors. Our results indicate that normal aging-related dopamine physiology i...Continue Reading

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Citations

Jul 25, 2012·Experimental Gerontology·Xin FengStephen B Kritchevsky
Jan 15, 2014·Neurobiology of Aging·Mayur S ParmarJane E Cavanaugh
Mar 5, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Di WuXunming Ji
Jun 11, 2021·Science Translational Medicine·Zongping FangLize Xiong

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