PMID: 7538342Jan 1, 1994Paper

Age-related decline in proliferative potential of purified stem cell candidates

Blood Cells
P M LansdorpH Mayani

Abstract

Recent studies in our laboratory have shown striking differences in the functional properties of candidate hematopoietic stem cells purified from fetal, neonatal, and adult human tissues. These differences include the ability to produce CD34+ cells, the turnover rate, and the fraction of cells that respond to a mixture of cytokines. All these parameters decrease with the age of the cell donor, and some of these observations are summarized here. Extensive qualitative changes in hematopoietic cells from various stages of development should be taken into account in the design of novel therapeutic strategies.

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Advances in Experimental Medicine and Biology
Taner Demirer
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
L Li, X Pei
[Rinshō ketsueki] The Japanese journal of clinical hematology
Fumihiko Ishikawa
© 2021 Meta ULC. All rights reserved