PMID: 8951461Dec 1, 1996Paper

Age-related decreases in endocochlear potential are associated with vascular abnormalities in the stria vascularis

Hearing Research
M A GrattonBradley A Schulte

Abstract

The density and diameter of strial capillaries were assessed in whole-mount preparations of the cochlear lateral wall from 18 gerbils aged in quiet for at least 36 months. Following morphometric analysis, histopathologic changes in selected regions of the lateral wall were examined by light and transmission electron microscopy. Alterations in strial vasculature were compared with the endocochlear potential (EP) measurements from the same ear. Vascular degeneration occurred in a segmental fashion in that regions of atrophic capillaries were found throughout the cochlea but primarily in the apical and lower basal turns and in the hook. The amount of stria with normal capillaries varied greatly among the aged ears, ranging from 19 to 87%. The resting EP also varied markedly, ranging from 23 to 83 mV. Little correlation was found between vascular alterations and the corresponding EP value from individual cochlear turns. However, significant correlations were found between the total strial area with normal vasculature and both the mean EP value and that recorded at either the round window or first turn in that ear.

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Citations

Apr 18, 2008·Cell and Tissue Research·Otto Gleich, Ana Luisa Piña
Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·H LangR A Schmiedt
Dec 24, 2003·Journal of the Association for Research in Otolaryngology : JARO·Tao Wu, Daniel C Marcus
Feb 21, 2004·Journal of the Association for Research in Otolaryngology : JARO·Ingo HamannJürgen Strutz
Aug 4, 2007·Journal of the Association for Research in Otolaryngology : JARO·Rodney C DiazEbenezer N Yamoah
Aug 14, 2010·Journal of the Association for Research in Otolaryngology : JARO·Kevin K OhlemillerPatricia M Gagnon
May 24, 2012·Journal of the Association for Research in Otolaryngology : JARO·Mark A EckertJudy R Dubno
Mar 21, 2013·Journal of the Association for Research in Otolaryngology : JARO·Mark A EckertJudy R Dubno
Jan 15, 2002·Hearing Research·George A GatesEdwin W Rubel
Oct 4, 2002·Hearing Research·Samuel S Spicer, Bradley A Schulte
Nov 16, 2002·Hearing Research·Denise LaMarche HeaneyAndrew S Niedzielski
Nov 5, 1997·Hearing Research·S L McFaddenD Henderson
Mar 19, 1999·Hearing Research·R WuM Nagura
Nov 5, 1999·Hearing Research·U LangemannA Friebe
Aug 24, 2007·Audiology & Neuro-otology·Michael Anne GrattonJames C Saunders
Feb 4, 2006·The Journal of the Acoustical Society of America·E OzimekE Szymiec
Jan 30, 2016·Acta Oto-laryngologica·Mattia Carraro, Robert V Harrison
May 29, 2012·Hearing Research·John J GuinanMary Ann Cheatham
Jan 8, 2011·Experimental Gerontology·Anna R FetoniDiana Troiani
Jun 25, 2008·Hearing Research·Su-Hua ShaJochen Schacht
Aug 12, 2006·Hearing Research·Kevin K OhlemillerPatricia M Gagnon
Jul 11, 2006·Neurobiology of Aging·Sherif F TadrosRobert D Frisina
Feb 9, 2006·Neurobiology of Aging·Jiri PopelarJosef Syka
May 1, 2012·Neurobiology of Aging·Clara KurniawanEric van Exel
Feb 24, 1998·Hearing Research·J F WillottW A Falls
Aug 30, 2016·Experimental Gerontology·Otto GleichJürgen Strutz

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