Age-related defects in the cytoskeleton signaling pathways of CD4 T cells.

Ageing Research Reviews
Gonzalo G Garcia, Richard A Miller

Abstract

It has been postulated that the cytoskeleton controls many aspects of T cell function, including activation, proliferation and apoptosis. Recent advances in our understanding of F-actin polymerization and the Ezrin-Radixin-Moesin (ERM) family of cytoskeleton signal proteins have provided new insights into immunological synapse formation during T cell activation. During aging there is a significant decline of T cell function largely attributable to declines in activation of CD4 T cells and defects in the formation of the immunological synapse. Here we discuss recent progress in the understanding of how aging alters F-actin and ERM proteins in mouse CD4 T cells, and the implications of these changes for the T cell activation process.

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Oct 11, 2011·Cellular & Molecular Immunology·Stefania CaneUsha Ponnappan
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Apr 4, 2021·International Journal of Molecular Sciences·Silvia Ferrari, Maurizio Pesce
May 11, 2021·Frontiers in Immunology·Jayashree SrinivasanEllen R Richie

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