PMID: 15374495Jul 1, 1990Paper

Age-related deterioration of long-term potentiation in the CA3 and CA1 regions of hippocampal slices from the senescence-accelerated mouse

Archives of Gerontology and Geriatrics
H KatsukiM Satoh

Abstract

Long-term potentiation (LTP) is one candidate for the mechanism underlying memory storage. In the present study, we carried out electrophysiological studies on hippocampal slices prepared from the senescence-accelerated mouse (SAM-P/8), a strain which shows accelerated senescence and failure of certain types of learning in behavioral tests. The findings were compared with those noted in the SAM-R/1 substrain without severe symptoms of senescence. No significant differences were found between SAM-R/1 and SAM-P/8 of the same ages in responses in the absence of tetanic stimulation, and in LTP after tetanic stimulation. However, there were marked decreases in the degree of potentiation with aging in both strains.

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Jun 1, 1988·Canadian Journal of Physiology and Pharmacology·B R SastryS S Chirwa
Jan 1, 1985·Annals of the New York Academy of Sciences·D S Olton
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Oct 1, 1981·Mechanisms of Ageing and Development·T TakedaT Yamamuro

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Citations

Mar 10, 1998·Neuroscience and Biobehavioral Reviews·J F Flood, J E Morley
Jul 22, 2015·Experimental Brain Research·Sakiko TaniguchiKoichi Ito
Jun 15, 2011·Neurobiology of Aging·Juan Carlos López-RamosJosé M Delgado-García
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M OkadaM Fujiwara
Sep 1, 1991·Journal of the American Geriatrics Society·T TakedaK Higuchi

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