Age-related development of a refractive index plateau in the human lens: evidence for a distinct nucleus

Clinical & Experimental Optometry : Journal of the Australian Optometrical Association
Robert C AugusteynJames M Pope

Abstract

The human lens comprises two distinct regions in which the refractive index changes at different rates. The periphery contains a rapidly increasing refractive index gradient, which becomes steeper with age. The inner region contains a shallow gradient, which flattens with age, due to formation of a central plateau, of RI = 1.418, which reaches a maximum size of 7.0 x 3.05 mm around age 60 years. Formation of the plateau can be attributed to compression of fibre cells generated in prenatal life. Present in prenatal but not in postnatal fibre cells, gamma-crystallin may play a role in limiting nuclear cell compression.

References

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Jan 1, 1987·Vision Research·B PierscionekR C Augusteyn
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Sep 13, 2002·Australian Veterinary Journal·R C Augusteyn

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Citations

Jan 1, 2011·Journal of Modern Optics·A de CastroS Marcos
Sep 4, 2010·Journal of Neuroscience Methods·Tatiana V Tkatchenko, Andrei V Tkatchenko
Oct 9, 2008·Experimental Eye Research·Steven Bassnett
Mar 20, 2016·Experimental Eye Research·Steven Bassnett, M Joseph Costello
Feb 17, 2015·Progress in Retinal and Eye Research·Rafael Iribarren
Apr 4, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Robert C Augusteyn
Mar 12, 2008·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Robert C Augusteyn
Oct 21, 2009·Current Eye Research·Fatih Mehmet MutluAtilla Bayer
Oct 10, 2019·Investigative Ophthalmology & Visual Science·Lene A HagenRigmor C Baraas
Aug 29, 2020·Translational Vision Science & Technology·Alyssa L LieEhsan Vaghefi
Jul 28, 2018·Journal of Ophthalmology·Joaquín FernándezDavid P Piñero
Jul 7, 2019·Vision Research·Tomasz M Kozłowski, Ronald H H Kröger
Jul 23, 2021·Investigative Ophthalmology & Visual Science·Alyssa L LiePaul J Donaldson

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