Age-Related Development of Cardiac Remodeling and Dysfunction in Young Black and White Adults: The Coronary Artery Risk Development in Young Adults Study.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Amanda M PerakDonald M Lloyd-Jones

Abstract

Little is known about the timing of preclinical heart failure (HF) development, particularly among blacks. The primary aims of this study were to delineate age-related left ventricular (LV) structure and function evolution in a biracial cohort and to test the hypothesis that young-adult LV parameters within normative ranges would be associated with incident stage B-defining LV abnormalities over 25 years, independent of cumulative risk factor burden. Data from the Coronary Artery Risk Development in Young Adults study were analyzed. Participants (n = 2,833) had a mean baseline age of 30.1 years; 45% were black, and 56% were women. Generalized estimating equation logistic regression was used to estimate age-related probabilities of stage B LV abnormalities (remodeling, hypertrophy, or dysfunction) and logistic regression to examine risk factor-adjusted associations between baseline LV parameters and incident abnormalities. Cox regression was used to assess whether baseline LV parameters associated with incident stage B LV abnormalities were also associated with incident clinical (stage C/D) HF events over >25 years' follow-up. Probabilities of stage B LV abnormalities at ages 25 and 60 years were 10.5% (95% CI, 9.4%-11.8%) and 4...Continue Reading

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Citations

Jan 17, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Alan C KwanSusan Cheng
Jun 4, 2021·Current Cardiology Reports·Ramachandran S VasanVanessa Xanthakis
Jun 10, 2021·Hypertension·Samuel S Gidding
Jul 17, 2021·Journal of the American College of Cardiology·Donald M Lloyd-JonesJared P Reis

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