Age-related differences in elevated plus maze behavior between adolescent and adult rats

Annals of the New York Academy of Sciences
Tamara L DoremusLinda P Spear

Abstract

Adolescence is a time of considerable transformations, often associated with increases in risk taking and novelty-seeking behaviors. Little is known of a possible age-dependent expression of anxiety-related behaviors in novel or potentially dangerous situations. The present study explored age differences in anxiogenic and anxiolytic stimuli between adolescent and adult Sprague-Dawley rats using the elevated plus maze (EPM). Data were compared across several experiments using factor analysis of multiple EPM measures. Under some circumstances, adolescents revealed a relatively low behavioral anxiety profile compared to adults, whereas in other situations results revealed the opposite pattern. Characteristics of the pretest circumstances altered considerably the nature of the conclusions reached regarding age-related changes in anxiogenic and anxiolytic stimuli. In general, anxiety measures in adolescents were less affected by variations in pretest conditions compared to the same variables in adults, suggesting possible adolescent immaturity of brain mechanisms involved in the regulation of anxiety.

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Citations

Jan 11, 2007·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
Dec 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brian BinghamRita Valentino
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julia VaglenovaClark Randal
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fabiana BandeiraSuzana Herculano-Houzel
Jul 16, 2013·Journal of Visualized Experiments : JoVE·Robert M J Deacon
Mar 13, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea Hetzel, J Amiel Rosenkranz
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Oct 28, 2008·Behavioural Brain Research·Krysta M FoxElisabeth J Van Bockstaele
Aug 21, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sagrario Martín-AragónJuana Benedí
Jul 28, 2005·Alcoholism, Clinical and Experimental Research·Sören SiegmundRainer Spanagel
Sep 1, 2007·Alcoholism, Clinical and Experimental Research·Tamara L Doremus-Fitzwater, Linda P Spear
Jan 6, 2009·Alcoholism, Clinical and Experimental Research·David N LinsenbardtStephen L Boehm
Mar 1, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wei Zhang, J Amiel Rosenkranz
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Sep 9, 2006·Behavioural Brain Research·Takefumi KikusuiYuji Mori
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Mar 17, 2020·Psychopharmacology·Eliana FerreyraRoberto Sebastián Miranda-Morales
Oct 14, 2020·Developmental Psychobiology·Indra R BishnoiMartin Kavaliers
Jun 19, 2021·Experimental Brain Research·Hiyori MatsumotoHirotaka Kosaka

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