Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza-U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET)

Open Forum Infectious Diseases
Christopher A CzajaRachel K Herlihy

Abstract

Rates of influenza hospitalizations differ by age, but few data are available regarding differences in laboratory-confirmed rates among adults aged ≥65 years. We evaluated age-related differences in influenza-associated hospitalization rates, clinical presentation, and outcomes among 19 760 older adults with laboratory-confirmed influenza at 14 FluSurv-NET sites during the 2011-2012 through 2014-2015 influenza seasons using 10-year age groups. There were large stepwise increases in the population rates of influenza hospitalization with each 10-year increase in age. Rates ranged from 101-417, 209-1264, and 562-2651 per 100 000 persons over 4 influenza seasons in patients aged 65-74 years, 75-84 years, and ≥85 years, respectively. Hospitalization rates among adults aged 75-84 years and ≥85 years were 1.4-3.0 and 2.2-6.4 times greater, respectively, than rates for adults aged 65-74 years. Among patients hospitalized with laboratory-confirmed influenza, there were age-related differences in demographics, medical histories, and symptoms and signs at presentation. Compared to hospitalized patients aged 65-74 years, patients aged ≥85 years had higher odds of pneumonia (aOR, 1.2; 95% CI, 1.0-1.3; P = .01) and in-hospital death or trans...Continue Reading

References

Oct 18, 2002·Journal of the American Geriatrics Society·Edward E WalshAnn R Falsey
Mar 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Larry J StrausbaughCarol L Joseph
Nov 30, 2005·Archives of Internal Medicine·Aaron T CurnsLawrence B Schonberger
Dec 22, 2005·International Journal of Epidemiology·Lisa A JacksonNoel S Weiss
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel A MandellUNKNOWN American Thoracic Society
Oct 31, 2009·Journal of the American Geriatrics Society·Elena N NaumovaPaula Minihan
Jan 26, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nila J DharanAlicia M Fry
Oct 1, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·UNKNOWN Centers for Disease Control and Prevention
Apr 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hong ZhouDavid K Shay
May 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shikha GargAlicia M Fry
Feb 12, 2013·Lancet·Andrew CleggKenneth Rockwood
Jun 28, 2013·Science Translational Medicine·Sourya ShresthaPejman Rohani
Jul 17, 2013·American Journal of Respiratory and Critical Care Medicine·Justin R OrtizChristopher H Goss
Aug 27, 2013·BMJ : British Medical Journal·Dominik MertzMark Loeb
Nov 6, 2013·American Journal of Epidemiology·Talia M QuandelacyEdward Goldstein
May 14, 2014·Current Opinion in Immunology·Gregory A PolandJames L Kirkland
Mar 26, 2015·PloS One·Mary Louise LindegrenH Keipp Talbot
Jul 15, 2015·The New England Journal of Medicine·Seema JainUNKNOWN CDC EPIC Study Team
Aug 11, 2015·Influenza and Other Respiratory Viruses·Ann R FalseyEdward E Walsh
Aug 21, 2015·Emerging Infectious Diseases·Sandra S ChavesLyn Finelli
Oct 22, 2015·Scientific Reports·Sourya ShresthaPejman Rohani
Oct 28, 2015·Influenza and Other Respiratory Viruses·Su SuSandra S Chaves
May 5, 2017·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Walter W WilliamsAmy Parker Fiebelkorn
May 20, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carmen ArriolaSandra S Chaves
Jul 12, 2017·Influenza and Other Respiratory Viruses·Louise E LansburyJonathan S Nguyen-Van-Tam
Aug 26, 2017·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Lisa A GrohskopfDaniel B Jernigan
Sep 22, 2017·The Journal of Infectious Diseases·Melissa K AndrewUNKNOWN Serious Outcomes Surveillance Network of the Public Health Agency of Canada/Canadian Institutes of Healt
Mar 6, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy M UyekiAndrew T Pavia

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Citations

Feb 6, 2020·Influenza and Other Respiratory Viruses·Mathilde PivetteBruno Hubert
Mar 18, 2020·International Journal of Environmental Research and Public Health·Francesca MorettiEmanuele Torri
Sep 13, 2020·Aging Clinical and Experimental Research·Salvatore CaratozzoloUNKNOWN COVIDEM Network
Mar 20, 2021·Cell·Stuart P WeisbergDonna L Farber
Oct 11, 2020·Maturitas·Guillaume SaccoCédric Annweiler
Jul 2, 2021·Scientific Reports·Núria SoldevilaUNKNOWN Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group

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